Assoc. Prof. MD.
Zeynep Ocak
Genetic
Interests
• Clinical Genetics
• Genetic Analyses in Recurrent Miscarriages and Risky Pregnancies
• Genetic Diagnosis and Screening in IVF Treatments
• Infertility
• Genetic Typing for Targeted Drug Therapy in the Treatment of Cancer
Education:
• 2001 - Atatürk University, Faculty of Medicine - Medicine Training
• 2007 - Atatürk University, Medical Genetics Department - Medical Genetics Residency Training
• 2011 - Abant Izzet Baysal University, Faculty of Medicine - Medical Genetics Department - Asst. Prof. Dr.
• 2014 - Abant Izzet Baysal University, Faculty of Medicine - Medical Genetics Department - Assoc. Prof. Dr.
• 2019 - Istinye University, Faculty of Medicine - Medical Genetics Department - Assoc. Prof. Dr.
Experience:
• Liv Hospital Ulus
• 2019 - Istinye University, Faculty of Medicine - Medical Genetics Department - Assoc. Prof. Dr.
• 2017-2019 - Yeni Yüzyıl University, Faculty of Medicine - Medical Biology and Genetics Department - Assoc. Prof. Dr.
• 2016-2017 - Dışkapı Yıldırım Beyazıt Training and Research Hospital - Transplantation Immunology, Tissue Typing and Transplantation Laboratory - Assoc. Prof. Dr.
• 2014-2016 - Kanuni Sultan Süleyman Training and Research Hospital - Assoc. Prof. Dr.
• 2013-2014- Research Center for Genomic Medicine, Saitama Medical University, Saitama 350-1241, Japan-Researcher
• 2011-2013 - Abant İzzet Baysal University, Faculty of Medicine - Medical Genetics Department - Asst. Prof. Prof. Dr.
• 2008-2011 - Süleymaniye Gynecology and Obstetrics Training and Research Hospital - Medical Genetics Residency
• 2003-2007 - Atatürk University Medical Genetics Department - Research Assistant Dr.
• 2001 - Atatürk University, Faculty of Medicine - Medicine Training
• 2007 - Atatürk University, Medical Genetics Department - Medical Genetics Residency Training
• 2011 - Abant Izzet Baysal University, Faculty of Medicine - Medical Genetics Department - Asst. Prof. Dr.
• 2014 - Abant Izzet Baysal University, Faculty of Medicine - Medical Genetics Department - Assoc. Prof. Dr.
• 2019 - Istinye University, Faculty of Medicine - Medical Genetics Department - Assoc. Prof. Dr.
Experience:
• Liv Hospital Ulus
• 2019 - Istinye University, Faculty of Medicine - Medical Genetics Department - Assoc. Prof. Dr.
• 2017-2019 - Yeni Yüzyıl University, Faculty of Medicine - Medical Biology and Genetics Department - Assoc. Prof. Dr.
• 2016-2017 - Dışkapı Yıldırım Beyazıt Training and Research Hospital - Transplantation Immunology, Tissue Typing and Transplantation Laboratory - Assoc. Prof. Dr.
• 2014-2016 - Kanuni Sultan Süleyman Training and Research Hospital - Assoc. Prof. Dr.
• 2013-2014- Research Center for Genomic Medicine, Saitama Medical University, Saitama 350-1241, Japan-Researcher
• 2011-2013 - Abant İzzet Baysal University, Faculty of Medicine - Medical Genetics Department - Asst. Prof. Prof. Dr.
• 2008-2011 - Süleymaniye Gynecology and Obstetrics Training and Research Hospital - Medical Genetics Residency
• 2003-2007 - Atatürk University Medical Genetics Department - Research Assistant Dr.
Publications: (28)
• A1. Oztas S, Salman AB, Tatar A, Yigiter M, Yazgi H, Ertek M, Yesilyurt A, Ocak Z, Kürşat H. Genotoxic effect of albendazole in pediatric patients with hepatic hydatid disease. International Journal of Infectious Disease 2007; 11: 446-449
• A2. Tatar A, Ocak Z, Doneray H, Isık E, Yesilyurt A, Ozkan B, Oztas S: Seckel syndrome with spontaneous chromosomal instability: a case report, Turkish Journal of Medical Sciences 2008; 38: 77-81
• A3. Tatar A, Ocak Z, Tatar A, Yesilyurt A, Borekci B, Oztas S. Primary hypogonadism, partial alopecia, and mullerian hypoplasia: report of a third family and review. American journal of medical genetics. Part A 2009; 149A, 501-504
• A4. Yazıcıoglu F, Ocak Z. Walker-Warburg syndrome with hyperplastic primary vitreus detected by prenatal ultrasonography: case report. Ultrasound in Obstetrics and Gynecolgy 2010; 35: 247-249
• A5. Ocak Z, Surucu R. Molecular cytogenetic characterization of a case of primary amenorrhea with intrachromosomal triplication of the X chromosome q arm. Genetic counseling. 2012;23: 297-304.
• A6. Ocak Z, Göksügür S.B, Kocaman E.M. Dirençli epilepsi olgusunda mozaik ring kromozom 6 ve klinik önemi. Turkish Archives of Pediatrics 2012; 47: 315-6
• A7. Ocak Z, Yazıcıoğlu HF, Aygün M, Ilter MKI, Ozlu T. Prenatal detection of Pai syndrome without cleft lip and palate: a case report. Genetic counseling. 2013; 24: 1-5
• A8. Ocak T, Ocak Z, Duran A, Bilgi M, Demirhan A, Şit M. The approach to the case of rarely seen adult morque syndrome at emergency service. South Eastern Europe Health Sciences Journal 2013; 3: 93-6.
• A9. Ocak Z, Ocak T, Duran A, Ozlü T, Kocaman E.M. Frequency of MEFV mutation and genotype-phenotype correlation in cases with dysmenorrhea. The Journal of Obstetrics and Gynaecology Research 2013; 8:1314-8
• A10. Ocak Z, Ozlu T, Vural M. Anal atresia, abnormal genitalia and absent thumb: congenital malformations associated with mosaic ring chromosome 13. Genetic counseling 2013; 24: 157-60
• A11. Ocak Z, Ozlü T, Ozyurt O. The association of recurrent pregnancy loss with chromosomal abnormalities and hereditary thrombophilias. The African Health Sciences 2013; 13: 465-70
• A12. Ocak Z, Acar M, Gundüz E, Gundüz M, Demircan K, Uyeturk U, Ozlü T. Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells. European Review for Medical and Pharmacological Sciences 2013; 17: 1185-90
• A13. Baris I, Etlik O, Koksal V, Ocak Z, Baris ST. SYBR green dye-based probe-free SNP genotyping: introduction of T-Plex real-time PCR assay. Anal Biochem. 2013; 441: 225- 31.
• A14. Dınçer M, Karahasanoglu A, Çılıngır U, Ozdemır M.E, Ocak Z, Karahuseyınoglu S, Yucel O, Frequency of Y chromosome microdeletions and chromosomal abnormalities in infertile Turkish men. Genet Couns. 2013; 24: 431-4.
A15. Tarik O, Zeynep O, Hasan D, Mustafa U, Ahmet Y, Mevlit I, Sahin A. Relationship between carbon monoxide intoxication and sister chromatid Exchange in lymphocytes. Toxicol Ind Health. 2014; 10: 896-900
• A16. Ocak Z, Üyetürk U, Dinçer M. Clinical and prognostic importance of chromosomal abnormalities, Y chromosome microdeletions and CFTR gene mutations in the individuals who have azoospermia and severe oligospermia. Turkish Journal of Medical Sciences 2014; 2:347-51.
• A17. Ocak Z, Ozlü T, Yazıcıoğlu H.F, Aygün M, Özyurt O. Clinical and cytogenetic results of a large series of amniocentesis cases from turkey: report of 6124 cases. The Journal of Obstetrics and Gynaecology Research 2014; 1:139-46.
• A18. Özlü T, Ocak Z, Ozyurt O. Prenatal diagnosis of Pallister Killian syndrome in a fetus with congenital diaphragmatic hernia, short limbs and ıncreased nuchal translucency. Taiwanese Journal of Obstetrics and Gynecology 2014; 3: 404-5
• A19. Ocak T, Duran A, Özyalvaçli G, Ocak Z, Terzi H.E, Tosun M, Erdem K. Protective effects of montelukast and hypericum perforatum against ıntestinal ıschemia-reperfusion ınjury in hamsters. Turkish Journal of Medical Sciences 2014; 3: 381-6.
• A20. Ocak Z, Özlü T, Tasdemir S, Bilen H, Kocaman E.M. Are there any genotoxic effects of laser epilation applications on human? An observational study. Natl J Physiol Pharm Pharmacol. 2014; 1: 43-46
• A21. Ozlü T, Ocak Z, Serap Simavlı A, Karatas A. Polymorphisms of Toll Like Receptor 2,3 and 4 in patients that do and do not enter labor spontaneously at term. Journal of Obstetrics and Gynaecology 2014; 6: 476-8
• A22. Acar M, Ocak Z, Erdogan K, Cetin EN, Hatipoglu OF, Uyeturk U, Gunduz E, Gunduz M. The effects of hypericin on ADAMTS and p53 gene expression in MCF-7 breast cancer cells. J BUON. 2014; 3: 627-32.
• A23. Gulec EY, Ocak Z, Candan S, Ataman E, Yarar C. Novel mutations in PTPN11 gene in two girls with Noonan syndrome phenotype. Int J Cardiol. 2015; 19;186:13-15.
• A24. Simavli H, Tosun M, Bucak Y, Erdurmus M, Ocak Z, Onder H, Acar M. Serum and aqueous xanthine oxidase levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliation, Graefes Arch Clin Exp Ophthalmol 2015; 253:1161–7
• A25. Aldemir S, Acar M, Ocak Z, Dalbudak E, Yiğitoğlu M.R, Gündüz E. Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with obsessive-compulsive disorder in a Turkish population. Klınık Psıkofarmakolojı Bultenı-Bulletın Of Clınıcal Psychopharmacology 2016;(baskıda)
• A26. Bornaun H. Oztarhan K, Ocak Z, Ulucan K, Buyukkale K, Gedikbası A. Contribution of TGFB1 and TNF-alpha genes in one of twin pregnancy with congenital complete heart block phenotype" International Journal of Cardiology 2016; 210:16-8
• A27. Özan Ü, Ocak Z, Özan F, Oktay EA, Toptaş O, Şahman H, Yikilgan I, Oruçoğlu H, Er K. Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk. Med Oral Patol Oral Cir Bucal. 2016; 21(4): e408-12.
• A28. Pehlivan D, Bayram Y, Gunes N, Coban Akdemir Z, Shukla A, Bierhals T, Tabakci B, Sahin Y, Gezdirici A, Fatih JM, Gulec EY, Yesil G, Punetha J, Ocak Z, Grochowski CM, Karaca E, Albayrak HM, Radhakrishnan P, Erdem HB, Sahin I, Yildirim T, Bayhan IA, Bursali A, Elmas M, Yuksel Z, Ozdemir O, Silan F, Yildiz O, Yesilbas O, Isikay S, Balta B, Gu S, Jhangiani SN, Doddapaneni H, Hu J, Muzny DM; Baylor-Hopkins Center for Mendelian Genomics, Boerwinkle E22, Gibbs RA, Tsiakas K, Hempel M, Girisha KM, Gul D, Posey JE, Elcioglu NH, Tuysuz B, Lupski JR. The Genomics of Arthrogryposis, a Complex Trait: Candidate Genes and Further Evidence for Oligogenic Inheritance. Am J Hum Genet. 2019 Jul 3;105(1):132-150.
• A1. Oztas S, Salman AB, Tatar A, Yigiter M, Yazgi H, Ertek M, Yesilyurt A, Ocak Z, Kürşat H. Genotoxic effect of albendazole in pediatric patients with hepatic hydatid disease. International Journal of Infectious Disease 2007; 11: 446-449
• A2. Tatar A, Ocak Z, Doneray H, Isık E, Yesilyurt A, Ozkan B, Oztas S: Seckel syndrome with spontaneous chromosomal instability: a case report, Turkish Journal of Medical Sciences 2008; 38: 77-81
• A3. Tatar A, Ocak Z, Tatar A, Yesilyurt A, Borekci B, Oztas S. Primary hypogonadism, partial alopecia, and mullerian hypoplasia: report of a third family and review. American journal of medical genetics. Part A 2009; 149A, 501-504
• A4. Yazıcıoglu F, Ocak Z. Walker-Warburg syndrome with hyperplastic primary vitreus detected by prenatal ultrasonography: case report. Ultrasound in Obstetrics and Gynecolgy 2010; 35: 247-249
• A5. Ocak Z, Surucu R. Molecular cytogenetic characterization of a case of primary amenorrhea with intrachromosomal triplication of the X chromosome q arm. Genetic counseling. 2012;23: 297-304.
• A6. Ocak Z, Göksügür S.B, Kocaman E.M. Dirençli epilepsi olgusunda mozaik ring kromozom 6 ve klinik önemi. Turkish Archives of Pediatrics 2012; 47: 315-6
• A7. Ocak Z, Yazıcıoğlu HF, Aygün M, Ilter MKI, Ozlu T. Prenatal detection of Pai syndrome without cleft lip and palate: a case report. Genetic counseling. 2013; 24: 1-5
• A8. Ocak T, Ocak Z, Duran A, Bilgi M, Demirhan A, Şit M. The approach to the case of rarely seen adult morque syndrome at emergency service. South Eastern Europe Health Sciences Journal 2013; 3: 93-6.
• A9. Ocak Z, Ocak T, Duran A, Ozlü T, Kocaman E.M. Frequency of MEFV mutation and genotype-phenotype correlation in cases with dysmenorrhea. The Journal of Obstetrics and Gynaecology Research 2013; 8:1314-8
• A10. Ocak Z, Ozlu T, Vural M. Anal atresia, abnormal genitalia and absent thumb: congenital malformations associated with mosaic ring chromosome 13. Genetic counseling 2013; 24: 157-60
• A11. Ocak Z, Ozlü T, Ozyurt O. The association of recurrent pregnancy loss with chromosomal abnormalities and hereditary thrombophilias. The African Health Sciences 2013; 13: 465-70
• A12. Ocak Z, Acar M, Gundüz E, Gundüz M, Demircan K, Uyeturk U, Ozlü T. Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells. European Review for Medical and Pharmacological Sciences 2013; 17: 1185-90
• A13. Baris I, Etlik O, Koksal V, Ocak Z, Baris ST. SYBR green dye-based probe-free SNP genotyping: introduction of T-Plex real-time PCR assay. Anal Biochem. 2013; 441: 225- 31.
• A14. Dınçer M, Karahasanoglu A, Çılıngır U, Ozdemır M.E, Ocak Z, Karahuseyınoglu S, Yucel O, Frequency of Y chromosome microdeletions and chromosomal abnormalities in infertile Turkish men. Genet Couns. 2013; 24: 431-4.
A15. Tarik O, Zeynep O, Hasan D, Mustafa U, Ahmet Y, Mevlit I, Sahin A. Relationship between carbon monoxide intoxication and sister chromatid Exchange in lymphocytes. Toxicol Ind Health. 2014; 10: 896-900
• A16. Ocak Z, Üyetürk U, Dinçer M. Clinical and prognostic importance of chromosomal abnormalities, Y chromosome microdeletions and CFTR gene mutations in the individuals who have azoospermia and severe oligospermia. Turkish Journal of Medical Sciences 2014; 2:347-51.
• A17. Ocak Z, Ozlü T, Yazıcıoğlu H.F, Aygün M, Özyurt O. Clinical and cytogenetic results of a large series of amniocentesis cases from turkey: report of 6124 cases. The Journal of Obstetrics and Gynaecology Research 2014; 1:139-46.
• A18. Özlü T, Ocak Z, Ozyurt O. Prenatal diagnosis of Pallister Killian syndrome in a fetus with congenital diaphragmatic hernia, short limbs and ıncreased nuchal translucency. Taiwanese Journal of Obstetrics and Gynecology 2014; 3: 404-5
• A19. Ocak T, Duran A, Özyalvaçli G, Ocak Z, Terzi H.E, Tosun M, Erdem K. Protective effects of montelukast and hypericum perforatum against ıntestinal ıschemia-reperfusion ınjury in hamsters. Turkish Journal of Medical Sciences 2014; 3: 381-6.
• A20. Ocak Z, Özlü T, Tasdemir S, Bilen H, Kocaman E.M. Are there any genotoxic effects of laser epilation applications on human? An observational study. Natl J Physiol Pharm Pharmacol. 2014; 1: 43-46
• A21. Ozlü T, Ocak Z, Serap Simavlı A, Karatas A. Polymorphisms of Toll Like Receptor 2,3 and 4 in patients that do and do not enter labor spontaneously at term. Journal of Obstetrics and Gynaecology 2014; 6: 476-8
• A22. Acar M, Ocak Z, Erdogan K, Cetin EN, Hatipoglu OF, Uyeturk U, Gunduz E, Gunduz M. The effects of hypericin on ADAMTS and p53 gene expression in MCF-7 breast cancer cells. J BUON. 2014; 3: 627-32.
• A23. Gulec EY, Ocak Z, Candan S, Ataman E, Yarar C. Novel mutations in PTPN11 gene in two girls with Noonan syndrome phenotype. Int J Cardiol. 2015; 19;186:13-15.
• A24. Simavli H, Tosun M, Bucak Y, Erdurmus M, Ocak Z, Onder H, Acar M. Serum and aqueous xanthine oxidase levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliation, Graefes Arch Clin Exp Ophthalmol 2015; 253:1161–7
• A25. Aldemir S, Acar M, Ocak Z, Dalbudak E, Yiğitoğlu M.R, Gündüz E. Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with obsessive-compulsive disorder in a Turkish population. Klınık Psıkofarmakolojı Bultenı-Bulletın Of Clınıcal Psychopharmacology 2016;(baskıda)
• A26. Bornaun H. Oztarhan K, Ocak Z, Ulucan K, Buyukkale K, Gedikbası A. Contribution of TGFB1 and TNF-alpha genes in one of twin pregnancy with congenital complete heart block phenotype" International Journal of Cardiology 2016; 210:16-8
• A27. Özan Ü, Ocak Z, Özan F, Oktay EA, Toptaş O, Şahman H, Yikilgan I, Oruçoğlu H, Er K. Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk. Med Oral Patol Oral Cir Bucal. 2016; 21(4): e408-12.
• A28. Pehlivan D, Bayram Y, Gunes N, Coban Akdemir Z, Shukla A, Bierhals T, Tabakci B, Sahin Y, Gezdirici A, Fatih JM, Gulec EY, Yesil G, Punetha J, Ocak Z, Grochowski CM, Karaca E, Albayrak HM, Radhakrishnan P, Erdem HB, Sahin I, Yildirim T, Bayhan IA, Bursali A, Elmas M, Yuksel Z, Ozdemir O, Silan F, Yildiz O, Yesilbas O, Isikay S, Balta B, Gu S, Jhangiani SN, Doddapaneni H, Hu J, Muzny DM; Baylor-Hopkins Center for Mendelian Genomics, Boerwinkle E22, Gibbs RA, Tsiakas K, Hempel M, Girisha KM, Gul D, Posey JE, Elcioglu NH, Tuysuz B, Lupski JR. The Genomics of Arthrogryposis, a Complex Trait: Candidate Genes and Further Evidence for Oligogenic Inheritance. Am J Hum Genet. 2019 Jul 3;105(1):132-150.
• Medical Genetics Association
• Turkish Medical Association
• Turkish Medical Association
Awards:
- Poster Second Place Award: Tatar A, Döneray H, Ocak Z, Marzioğlu E and Öztaş S, "A case with non-mosaic 49, XYYYY karyotype," VIII National Medical Genetics Congress, 284, Çanakkale, 2008
- Publication Incentive Programme Award, Abant İzzet Baysal University Research and Development Foundation, 2013
- Young Researcher Award, European Human Genetics Conference, Vienna, Austria, 2009
- Young Researcher Award, 13th Int. Congress of Human Genetics, Kyoto, Japan, 2016