Assoc. Prof. MD.

Hamdullah Sözen

Gynecology and Obstetrics

Ask Expert
Liv Hospital Vadistanbul
Interests

  • Gynecological Cancers (Over-Endometrium-Cervical cancer)
  • Endoscopic Surgery
  • Cervical pathologies/ Colposcope

Education
  • Akdeniz University Faculty of Medicine 2005
  • Zeynep Kamil Training and Research Hospital Gynecology and Obstetrics Specialization Training 2011
  • Istanbul University Istanbul Faculty of Medicine Gynecological Oncology Minor Specialization 2015

Experience
  • Istanbul Suleymaniye Training and Research Hospital 2015-2016
  • Istanbul University Istanbul Faculty of Medicine 2017-2021
Research
  • IMagyn050/GOG ​​3015/ENGOT-OV39. A Phase III, multicenter, randomized study of atezolizumab versus placebo administered in combination with paclitaxel, carboplatin, and bevacizumab to patients with newly-diagnosed stage III or stage IV ovarian, fallopian tube, or primary peritoneal cancer.
  • ENGOT-ov43/BGOG: Randomized phase III first line study in ovarian cancer comparing paclitaxel carboplatinum, with paclitaxel/carboplatin and pembrolizumab and olaparib
  • ERANET- PROMETOV Proteogenomic and targeted metabolomic analysis of ovarian cancer heterogeneity and its contribution to recurrence and therapy resistance.

Publications
  • Onder S, Hurdogan O, Bayram A, Yilmaz I, Sozen H, Yavuz E. The role of FOXL2, SOX9, and β-catenin expression and DICER1 mutation in differentiating sex cord tumor with annular tubules from other sex cord tumors of the ovary.
  • Virchows Arch. 2021 Feb 10. doi: 10.1007/s00428-021-03052-2. Online ahead of print.PMID: 33566167
  • Cuylan ZF, Akilli H, Gungorduk K, Demirkiran F, Oz M, Salman MC, Sozen H, Celik H, Gokcu M, Bese T, Meydanli MM, Ozgul N, Topuz S, Kuscu E, Kuru O, Gokmen S, Gultekin M , Ayhan A. Is the extent of lymphadenectomy a prognostic factor in International Federation of Gynecology and Obstetrics stage II endometrioid endometrial cancer?J Obstet Gynaecol Res. 2021 Mar;47(3):1134-1144. doi: 10.1111/jog.14648. Epub 2021 Jan 10.PMID: 33426779
  • Vatansever D, Taskiran C, Mutlu Meydanli M, Gungorduk K, Akbayir O, Yalcin I, Demirkiran F, Sozen H, Ozgul N, Celik H, Onan MA, Taskin S, Oge T, Simsek T, Abboud S, Yuksel IT, Ayhan A. Impact of cytoreductive surgery on survival of patients with low-grade serous ovarian carcinoma: A multicentric study of Turkish Society of Gynecologic Oncology (TRSGO-OvCa-001).J Surg Oncol. Mar 2021 3. doi: 10.1002/jso.26450. online ahead of print
  • Vatansever D, Sozen H, Sahin Ersoy G, Giray B, Topuz S, Iyibozkurt AC, Salihoglu Y Effect of Lymphadenectomy on Survival in Early-Stage Type II Endometrial Carcinoma and Carcinosarcoma. J Oncol. 2020 Apr 10;2020:1295613. doi: 10.1155/2020/1295613. eCollection 2020
  • Celik E, Kizildag Yirgin I, Goksever Celik H, Engin G, Sozen H, Ak N, Saip P, Onder S, Topuz S, Salihoglu MY Does visceral adiposity have an effect on the survival outcomes of the patients with endometrial cancer?
  • .J Obstet Gynaecol Res. 2021 Feb;47(2):560-569. doi: 10.1111/jog.14560. Epub 2020 Nov 16.PMID: 33197987
  • Keskin S, Küçük S, Ak N, Atalar B, Sarı M, Sozen H, Ibis K, Topuz S, Saip P. Survival Impact of Optimal Surgical Cytoreduction in Recurrent Epithelial Ovarian Cancer with Brain Metastasis. Oncol Res Treat. 2019;42(3):101-106. doi: 10.1159/000494334. Epub 2019 Jan 19.PMID: 30661076
  • Minareci Y, Tosun OA, Sozen H, Topuz S, Salihoglu MY. A Retrospective Clinical Analysis of Hyperthermic Intraperitoneal Chemotherapy in Gynecological Cancers: Technical Details, Tolerability, and Efficacy.Medeni Med J. 2020;35(3):202-211. doi: 10.5222/MMJ.2020.31855. Epub 2020 Sep 30.
  • Sozen H, Vatansever D, Topuz S et al. Clinicopathological analysis of borderline ovarian tumors and risk factors related to recurrence: experience of single institution. J Obstet Gynaecol. 2018 Oct 29:1-6. doi: 10.1080/01443615.2018.1499076. [Epub ahead of print
  • Kaban A, Topuz S, Sozen H.Does the Increased Rate of Serous Component (≤25% vs. >25%) Increase Recurrence in Endometrial Cancer With Serous Plus Endometrioid Histology? J Obstet Gynaecol Can. 2018 Oct 10th pii: S1701-2163(18)30096-3. doi: 10.1016/j.jogc.2018.03.002.
  • Kaban A, Topuz S, Saip P, Sözen H, Salihoğlu Y. Prognostic Factors in Patients Undergoing Primary Cytoreductive Surgery for FIGO Stage IIIC Ovarian, Tubal or Peritoneal Cancer. J Obstet Gynaecol Can. 2018 Apr;40(4):447-453. doi: 10.1016/j.jogc.2017.07.026. Epub 2017 Oct 18.
  • Kaban A1, Topuz S, Erdem B, Sozen H, Numanoğlu C, Salihoğlu Y. Is Omentectomy Necessary for Non-Endometrioid Endometrial Cancer Gynecol Obstet Invest. 2018;83(5):482-486. doi: 10.1159/000480237. Epub 2017 Aug 26.
  • Boyraz G1, Salman MC2, Gultekin M2, Ozkan NT3, Uckan HH2, Gungorduk K4, Gulseren V4, Ayik H5, Toptas T5, Kuru O2, Sozen H6, Erturk A2, Ozgul N2, Meydanlı MM3, Sanci M4, Turan T7, Gungor T3 , Simsek T5, Topuz S6, Yuce K2. What is the impact of stromal microinvasion on oncologic outcomes in borderline ovarian tumors? A multicenter case-control study. Arch Gynecol Obstet. 2017 Nov;296(5):979-987. doi: 10.1007/s00404-017-4496-4. Epub 2017 Sep 2.
  • Kaban A, Topuz S, Saip P, Sözen H, Salihoğlu Y. In patients with advanced ovarian cancer, primary suboptimal surgery has better survival outcome than interval suboptimal surgery. J Turk Ger Gynecol Assoc. 2018 Mar 16. doi: 10.4274/jtgga.2018.0015. [Epub ahead of print]
  • Kaban A, Topuz S, Sözen H, Minareci Y, Salihoğlu Y. Clinicopathologic and survival results in serous endometrium carcinoma and subgroup analysis for mixed serous and pure serous histology. J Turk Ger Gynecol Assoc. 2018 Mar 1;19(1):23-28. doi: 10.4274/jtgga.2017.0065. Epub 2017 Oct 26.
  • Kaban A1, Topuz S2, Saip P3, Sozen H2, Celebi K3, Salihoglu Y2. Poor Prognostic Factors in Patients Undergoing Surgery After Neoadjuvant Chemotherapy for Ovarian, Tubal, or Peritoneal Cancer. J Obstet Gynaecol Can. 2017 Dec;39(12):1163-1170. doi: 10.1016/j.jogc.2017.05.008. Epub 2017 Aug 4.
  • Ilhan G, Sozen H, Atmaca FFV, Zebitay AG, Gungor ES, Ergin AH. Uterocutaneous fistula after myomectomy: An unusual complication. J Cases Obstet Gynecol, 2017;4(2):41-44
  • Ilhan G, Atmaca FFV, Altan E, Zebitay AG, Sozen H, Akyol H, Kurek Eken M Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Red Blood Cell Distribution Width-Platelet Ratio for Diagnosis of Premature Ovarian Insufficiency. J Family Reprod Health. 2016 Dec;10(4):211-216
  • Onder S1, Taskin OC, Sen F, Topuz S, Kuucucuk S, Sozen H, Ilhan R, Tuzlali S, Yavuz E. High expression of SALL4 and fascin, and loss of E-cadherin expression in undifferentiated/dedifferentiated carcinomas of the endometrium: An immunohistochemical and clinicopathologic study. Medicine (Baltimore). 2017 Mar;96(10):e6248. doi: 10.1097/MD.0000000000006248
  • Vatansever D, Atici AE, Sozen H, Sakin O Diaphragmatic resection preserving and repairing pericardium, splenectomy and distal pancreatectomy for interval debulking surgery of ovarian cancer. Gynecol Oncol. 2016 Jul;142(1):206-7. doi: 10.1016/j.ygyno.2016.05.004. Epub 2016 May 19
  • Sal V, Demirkiran F, Topuz S, Kahramanoglu I, Yalcin I, Bese T, Sozen H, Tokgozoglu N, Salihoglu Y, Turan H, Iyibozkurt C, Kolomuc T, Sofiyeva N, Berkman S, Arvas M. Surgical Treatment of Metastatic Ovarian Tumors From Extragenital Primary Sites. IntJ Gynecol Cancer. 2016 May;26(4):688-96. doi: 10.1097/IGC.0000000000000673
  • Taskin OÇ, Onder S, Topuz S, Sozen H, Sen F, Ilhan R, Yavuz E. A Selected Immunohistochemical Panel Aids in Differential Diagnosis and Prognostic Stratification of Subtypes of High-grade Endometrial Carcinoma: A Immunopathologic and Immunohistochemical Study at a Single Clinic Institution . Appl Immunohistochem Mol Morphol. 2016 Apr 16. [Epub ahead of print]
  • Sozen H, Çiftçi R, Vatansever D, Topuz S, Iyibozkurt AC, Bozbey HU, Yaşa C, Çali H, Yavuz E, Kucucuk S, Aydiner A, Salihoglu Y. Combination of adjuvant chemotherapy and radiotherapy is associated with improved survival at early stage type II endometrial cancer and carcinosarcoma.Aust NZJ Obstet Gynaecol. 2016 Apr;56(2):199-206. doi: 10.1111/ajo.12449
  • Arvas M, Salihoglu Y, Sal V, Gungor T, Sozen H, Kahramanoglu I, Topuz S, Demirkiran F, Iyibozkurt C, Bese T, Ozgu BS, Vatansever D, Tokgozoglu N, Berkman S, Turan H, Bengisu E, Sofiyeva N , Demiral I, Meydanli M. Tertiary Cytoreduction for Recurrent Epithelial Ovarian Cancer: a Multicenter Study in Turkey. Asian Pac J Cancer Prev. 2016;17(4):1909-15
  • Topuz S, Sozen H, Vatansever D, Iyibozkurt AC, Ozgor BY, Bastu E, Salihoglu V, Berkman S. Do obesity and age effect the clinicopathological features and survival outcomes in premenopausal women with endometrial cancer? Eur J Gynaecol Oncol. 2016;37(3):320-6.
  • Sozen H, Vatansever D, Iyibozkurt AC, Topuz S, Ozsurmeli M, Salihoglu Y, Guzelbey B, Berkman S. Clinicopathologic and survival analyzes of synchronous primary endometrial and epithelial ovarian cancers. J Obstet Gynaecol Res. 2015 Nov;41(11):1813-9. doi: 10.1111/jog.12826
  • Namazov A, Karakus R, Gencer E, Sozen H, Acar L. Do submucous myoma characteristics affect fertility and menstrual outcomes in patients undergone hysteroscopic myomectomy? Iran J Reprod Med. 2015 Jun;13(6):367-72.
  • Vatansever D, Sozen H, Iyibozkurt AC, Comba C, Yavuz E, Topuz S. Extrapulmonary lymphangioleiomyomatosis mimicking lymphoma metastatic to uterus.J Obstet Gynaecol Res. 2015 May;41(5):823-7. doi: 10.1111/jog.12628
  • Yavuz A, Demirci O, Sözen H, Uludoğan M..Predictive factors influencing pregnancy rates after intrauterine insemination Iran J Reprod Med 2013 Mar;11(3):227-34
  • Sozen H, Namazov A, Cakir S, Akdemir Y, Vatansever D, Karateke A. .Pregnancy outcomes after cold knife conization related to excised cone dimensions. A retrospective cohort study. J Reprod Med. 2014 Jan-Feb;59(1-2):81-6
  • Bastu E, Akhan SE, Karamustafaoglu B, Gungor-Ugurlucan F, Sozen H, Iyibozkurt AC. A rare case of lymphangiomyomatosis treated with leuprolide acetate: five-years follow-up.. Eur J Gynaecol Oncol. 2013;34(3):278-9
  • Bastu E, Akhan SE, Ozsurmeli M, Galandarov R, Sozen H, Gungor-Ugurlucan F, Iyibozkurt AC.. Acute hemorrhage related to spontaneous rupture of an uterine fibroid: a rare case report.. Eur J Gynaecol Oncol. 2013;34(3):271-2.
  • Bastu E, Akhan SE, Karamustafaoglu B, Gungor-Ugurlucan F, Sozen H, Iyibozkurt AC.. Hemoperitoneum and acute abdomen caused by the rupture of ovarian granulosa cell tumor: a case report.. Eur J Gynaecol Oncol. 2013;34(3):263-4
  • Karateke A, Akdemir Y, Kucukbas M, Sozen H, Cam C. Recurrent ischiorectal abscess secondary to transobturator tape erosion: an unusual chronic complication. Eur J Obstet Gynecol Reprod Biol. 2011 Oct;158(2):364-5
  • blacksmith O,Tuğrul AS, Dolgun N, Sözen H, Eren S. Serum lipids level assessed in early pregnancy and risk of pre-eclampsia. J Obstet Gynaecol Res. 2011 Oct;37(10):1427-32.
  • Karaosmanoglu O, Cogendez E, Sozen H, Asoglu MR, Akdemir Y, Eren S.Hyaluronic acid in the treatment of postmenopausal women with atrophic vaginitis. Int J Gynaecol Obstet. 2011 May;113(2):156-7. doi: 10.1016/j.ijgo.2010.12.07. Epub 2011 Mar 21
  • Demirci O, Unal A, Demirci E, Sözen H, Akdemir Y, Boybek E, Ertekin A. Sonographic measurement of cervical length and risk of preterm delivery.J Obstet Gynaecol Res. 2011 Jul;37(7):809-14. doi: 10.1111/j.1447-0756.2010.01440.x. Epub 2011 Mar 13.
  • Akdemir Y, Ayvacı H, Demirci O, Sahin D, Demirağ E, Sözen H, Uludoğan M. Iniencephaly with mediastinal bronchogenic cyst: A case report J Prenat Med. 2010 Oct;4(4):74-6
  • Karateke A,Akdemir Y, Sozen H,Çakır S.Synchronous primary Heterologous type of malignant mixed mullerian tumor of the uterus and primary ovarian cancer. Gineco Ro Vol. 7 No. 23 1/2011
  • Küçükbaş M,Akdemir Y,Cevrioğlu S, Sozen H,Namazov A.Late diagnosis of pseudo-renal failure associated with bladder injury after cesarean section. Gineco Ro Vol 7 No.26 4/2011
  • Karateke A, Küçükbaş M, Sozen H, Namazov A, Çakır S, Akdemir Y. Fertility sparing surgery on placenta invasion anomalies and placenta previa. Iran J Reprod Med. 2012 May;10(3):271-4.
  • Sozen H, İlhan G, Vatansever D, Demirci O, Ertekin A Evaluation of the factors determining success in prostaglandin E2 treatment applied for cervical ripening Istanbul Medical Faculty Journal 2016 Dec
  • Salihoglu Y, Sözen H, Tosun Ş.A, İyibozkurt A.C, Berkman S, Bengisu E Lymph node metastases and patterns of recurrence in low-grade endometrial stromal sarcoma TRSGO journal 2014 Jan 79;3
  • Iyibozkurt A.C, Doğan M, Bastu E, Sözen H, Vatansever D, Topuz S,Berkman S, Efficacy of Endocervical Curettage and CA-125 Measurement in Endometrial Serous Carcinoma: a case series and literature review. J Turk Soc Obstet Gynecol. 2015; 12(3): 0-0
  • Ozdemir A, Cakır S, Sözen H, Namazov A, Akdemir Y, Karateke A. Development of bladder stone after tension free vaginal tape procedure: a case report. J Turk Ger Gynecol Assoc. 2011 Dec 1;12(4):256-8. doi: 10.5152/jtgga.2011.59. eCollection 2011.
  • Demirci O,Boybek E,Demirci E, Akdemir Y, Sözen H,Unal A, Soguktas S, Uludogan M Dinoprostone in Term Premature Rupture of Membranes Turkiye Klinikleri J Gynecol Obst 2011;21(2):94-9
  • Sozen H, Baktıroglu M, Yumru H, Usta İ, Yalçın İ, İbiş K, Küçük S, Topuz S, Salihoğlu Y The Effect of Limited Residual Tumor in the Uterus after Primary Chemoradiotherapy in Cervical Cancer. Zeynep Kamil Medical Bulletin 2018-49 (4): 348-352
  • Sozen H, Tosun Ö, Çelik E, Minareci Y, Yalçın İ, Vatansever D, Topuz S, Salihoğlu Y Gynecological Cancers and Pelvic Exenteration Short-Term Results Single Center Experiences Zeynep Kamil Medical Bulletin 2018-49 (4):353-356
  • TJOD Turkish Society of Gynecology and Obstetrics
  • TJOD Istanbul
  • TRSGO Turkish Society of Gynecological Oncology
  • MIJOD Minimally Invasive Gynecological Oncology Association
  • MIJID Minimally Invasive Gynecology Association
  • ESGO European Society of Gynecological Oncology
  • MEMAGO Middle East and Mediterranean Association of Gynecologic Oncologist

Ask Liv Expert