Prof. MD.

İlhan Elmacı

Neurosurgery

Interests

  • Brain tumors, skull base and spinal cord tumors:
    • Adults and children
      • Microsurgery and/or endoscopic surgeries:
      • Neuromonitoring, neuronavigation, under intraoperative neuroultrasonography control or with awake craniotomy.
      • Using microsurgical tumor staining techniques.
      • Neurooncology council planning in multidisciplinary treatment modeling
      • Immunotherapy and translational preclinical research and treatment planning
  • Pituitary adenomas:
    • Endoscopic pituitary surgery
      • With the skull base working group
    • Multidisciplinary treatment planning of adenomas
  • Brain hemorrhages and vascular diseases:
    • Microsurgical treatment in brain hemorrhages
    • Multidisciplinary planning and microsurgical treatment in brain aneurysms
    • Multidisciplinary planning and microsurgical treatment in cerebral vascular bundles
    • Microsurgical treatment of brain stem and spinal cord cavernomas
  • Back and neck pain
    • Non-surgical treatment planning for low back and neck pain
    • Microsurgical and endoscopic treatment of waist and neck hernias
    • Microsurgical treatment of low back and neck slippage:
      • Under O-arm CT neuronavigation and neuromonitorization control
    • Back and neck narrow canal microsurgery treatment
    • Filling treatment with local anesthesia in spinal compression fractures
  • Hydrocephalus/collection of brain water in the head
    • Shunt or endoscopic surgical treatment in adults or children
  • Trigeminal neuralgia and Hemifacial spasm
    • Microvascular decompression
  • Cerebellum prolapse
    • Syringomyelia/collection of brain juice within the spinal cord
      • Microsurgical treatment
      • Syringopleural shunt surgery
  • Spasticity
    • Selective dorsal rhizotomy
    • Baclofen pump therapy
  • Ethic
    • Principles of treatment planning as needed and protecting quality of life

Education
  • Ankara University Faculty of Medicine (Master's Degree)(1986)
  • Bakırköy Mental and Neurological Diseases Hospital (PhD/S. Qualification / Specialization in Medicine)(1993)

Experience
  • Bakırköy Mental and Neurological Diseases Hospital, II. Neurosurgery Clinic (Dr.Ar.Ass.)(1987-1993)
  • University of Zurich, Department of Neurosurgery (Microsurgery Fellowship) (1991-1992)
  • Bakırköy Mental and Neurological Diseases Hospital, II. Neurosurgery Clinic (Specialist)(1993-1995)
  • Marmara University Faculty of Medicine, Department of Neurosurgery (Lecturer)(1995-1997)
  • Johns Hopkins University School of Medicine, Department of Neurosurgery (Research Fellowship) (1997-1998)
  • Marmara University Faculty of Medicine, Department of Neurosurgery (Assist.Prof.)(1996-2003)
  • Marmara University Faculty of Medicine, Department of Neurosurgery (Associate Professor) (2003-2004)
  • SB Göztepe Training and Research Hospital Neurosurgery Clinic Chief (Associate Professor)(2004-2010)
  • Acıbadem University Department of Neurosurgery (Prof.)(2010-2012)
  • Founder of Medipol University Neurosurgery Department (Prof.)(2012-2014)
  • Memorial Health Group Istanbul Hospitals Neurosurgery Director (Prof.)(2014-2018)
  • Acıbadem Maslak Hospital 2nd Neurosurgery Group Director (Prof.)(2018-2021)
  • Liv Hospital Ulus Neurosurgery Department Director (Prof.)(2021-)
A. Articles published in international peer-reviewed journals
A1. Özgen S, Naderi S, Elmacı İ, Özek M, Pamir MN, “Lumbar disc herniations: An outcome analysis of 1473 operated patients,” Neuro-Orthopedics, 27, 43-53 (2000).
A2. Özgen S, Boran BO, Elmacı İ, Türe U, Pamir MN, “Treatment of the subarachnoidal-pleural fistula: A case report” Neurosurgical Focus, 9(1):Clinical Pearl, (2000).
A3. Ain MC, Elmacı İ, Hurko O, Clatterbuck RE, Lee RR, Rigamonti D, “Reoperation for spinal restenosis in achondroplasia” Journal of Spinal Disorders, 13(2):168-173 (2000).
A4. Elmacı İ, Ain MC, Wright MJ, Lee RR, Sheppard JM, Rigamonti D, Hurko O, “Perioperative intracranial hemorrhage in achondroplasia” J. Neurosurg. Anesthesiology, 12(3):217-220 (2000).
A5. Elmacı İ, “Colored illustrations and neurosurgical techniques of Şerefeddin Sabuncuoğlu in the 15th century” Neurosurgery, 47: 951-955 (2000).
A6. Clatterbuck RE, Moriarity JL, Elmaci I, Lee RR, Breiter SN, Rigamonti D,
“Dynamic nature of cavernous malformations: a proepective magnetic resonance imaging
  study with volumetric analysis” J Neurosurg, 93:981-986 (2000).
A7. Elmacı İ, Ateş G, Kurtkaya Ö, Pamir MN, “Chiasmal cavernous malformation: A rare cause of acute visual loss,” J Neurosurg Sci, 44(4):226-229 (2000)
A8. Elmacı İ, Kurtkaya Ö, Boran B, Kılıç T, Pamir MN, “Gliosarcoma associated with
Neurofibromatosis Type 1: A case report,” Tumori, 87:60-63 (2001).
A9. Kurtkaya Ö, Elmacı İ, Sav A, Pamir MN, “Spinal solitary fibrous tumor: seventh reported case and review of the literature,” Spinal Cord, 39:57-60 (2001).
A10. Elmacı İ, Dağçınar A, Özgen S, Ekinci G, Pamir MN, “Diastematomyelia and spinal teratoma in an adult. Case report,” Neurosurgical Focus, 10(1):Clinical Pearl 2 (2001).
A11. Ture U, İçdonmez T, Elmacı İ, Peker S, “Solid-calcified colloid cyst of the third ventricle,” Clin Neurol Neurosurg, 103(1):51-55 (2001).
A12. Elmaci İ, Ekinci G, Kurtkaya Ö, Sav A, Pamir MN, “Tumor in tumor: metastasis of breast carcinoma to intracranial meningioma,” Tumori, 87:423-427 (2001).
A13. Elmacı İ, Baltacıoğlu F, Ekinci G, Erzen C, Pamir MN, “Middle cerebral artery duplication associated with multiple intracranial aneurysms: case report,” J Neurosurg Sci, 45:232-234 (2001).
A14. Ture U, Hijdönmez T, Elmacı İ, Peker S, “Giant pericallosal artery aneurysm: a case report and review of literature,” Neurosurg Rev 24:151-155 (2001).
A15. Elmacı İ, Kurtkaya Ö, Peker S, Tuncer N, Adam B, Özgen S, Ekinci G, Türe U, Pamir MN, “Cervical spinal cord intramedullary abscess: case report,” J Neurosurg Sci 45:213-215 (2001).
A16. Clatterbuck RE, Elmacı İ, Rigamonti D, ”The nature and fate of punctate (Type IV) cavernous malformations,” Neurosurgery, 49:26-32 (2001).
A17. Elmacı İ, Kurtkaya-Yapıcıer Ö, Ekinci G, Sav A, Pamir MN, Vidal S, Kovacs K, Scheithauer BW, “Metastatic papillary craniopharyngioma: case report and study of tumor angiogenesis,” Neuro-Oncology, 4:123-128 ( 2002).
A18. Pamir MN, Özduman K, Elmacı İ, “Spinal hydatid disease: A review,” Spinal Cord, 40:153-160 (2002).
A19. Clatterbuck RE, Elmacı İ, Rigamonti D, “The juxtaposition of a capillary telengiectasia, CM, and developmental venous anomaly in the brain stem of a single patient” Neurosurgery, 49:1246-1250 (2001).
A20. Elmacı İ, “Coagulation (APC)” (Letter), Acta Neurochirurgica (Wien), 143:964 (2001).
A21. Kılıç T, Elmacı İ, Bayri Y, Pamir MN, Erzen C Value of transcranial doppler ultrasonography in the diagnosis and follow-up of carotid-cavernous fistulae
Acta Neurochirurgica (Wien) 143:1257-1265 (2001).
A22. Kılıç T, Ekinci G, Şeker A, Elmacı İ, Erzen C, Pamir MN, “Determining optimal MRI follow-up after transsphenoidal surgery for pituitary adenoma:scan at 24 hours postsurgery provides reliable information” Acta Neurochirurgica (Wien), 143:1103 -1126 (2001).
A23. Elmacı İ, Kurtkaya Ö, Ercan F, Tuncer N, Bakırcı N, San T, Sav A, Pamir MN, Tanrısever E, “The effects of quantum energy surgical device and of bipolar coagulation:
A comparative experimental study,” Acta Neurochirurgica (Wien), 144:377-383 (2002).
A24. Kılıç T, Elmacı İ, Özek M, Pamir N,”Utility of transcranial doppler ultrasonography in the diagnosis and follow-up of tuberculous meningitis-related vasculopathy” Child's Nerv Syst, 18:142-146, 2002
A25. Ekinci G, Akpınar İ, Baltacıoğlu F, Erzen C, Kılıç T, Elmacı İ, Pamir MN, “Early postoperative magnetic resonance imaging in glial tumors: prediction of tumor regrowth and recurrence,” European Journal of Radiology, 45:99-107 ( 2003).
A26. Türe U, Elmacı İ, Ekinci G, Pamir MN, “Totaly thrombosed giant P2 aneurysm. A case report and review of literature,” Journal of Clinical Neuroscience, 10:115-120 (2003).
A27. Türe U, Özduman K, Elmacı İ, Pamir MN, “Infratentorial lateral supracerebellar approach for trochlear nerve schwannoma,” Journal of Clinical Neuroscience, 9:595-598 (2002).
A28. Kurtkaya-Yapıcıer Ö, Elmacı İ, Boran B, Kılıç T, Pamir MN, “Dysembryoplastic neuroepithelial tumor of the midbrain tectum: A case report,” Brain Tumor Pathology, 19:97-100 (2002).
A29. Kılıç T, Özduman K, Elmacı İ, Sav A, Pamir MN, “Effect of surgery on tumor progression and malignant degeneration in hemispheric diffuse low-grade astrocytomas,” Journal of Clinical Neuroscience, 9:549-55 (2002).
A30. Ekinci G, Kılıç T, Baltacıoğlu F, Elmacı İ, Altun E, Pamir MN, Erzen C, “ The transsphenoidal (Large Craniopharyngeal) canal associated with normally functioning pituitary gland and nasopharyngeal extension, hyperprolactinemia, and hypothalamic hamartoma: Case report,” Am J Roentgenol. 180:76-77 (2003).
A31. Peker S, Sun İ, Kurtkaya-Yapıcıer Ö, Elmacı İ, Pamir MN, “Ectopic pituitary adenoma located at the pituitary stalk: case report,” Journal of Neurosurgical Sciences, 49:25-29 (2005)
A32. Kılıç T, Sohrabifar M, Kurtkaya Ö, Yıldırım Ö, Elmacı İ, Günel M, Pamir N, “Expression of structural proteins and angiogenic factors in normal arterial and unruptured and ruptured aneurysm walls”, Neurosurgery, 57:997-1007, 2005
A33. Işık N, Şerefhan A, Silav G, Elmacı İ, “Arnold Chiari type III malformation,” European Association of Radiology E-Learning initiative, Case 2639, 2005. 11.30
A34. Tuncer N, Yaycı N, Ekinci G, İnanıcı MA, Elmacı İ, “Intracranial sewing needle in a man with seziure: A case of child abuse?,” Forensic Science International, 168, 212-214, 2007
A35. Işık N, Silav G, Çerçi A, Karabağlı P, Elmacı İ, Kalelioğlu M, “Cerebral alveolar echinococcosis: A case report with MRI and review of the literature”, Journal of Neurosurgical Sciences, 51:145-151, 2007
A36. Elmacı İ, Şendağ D, Silav G, Ekenel F, Balak N, Ayan E, Akıncı M, Işık N, Yazıcı S, “Nocardial cerebral abscess associated withj mycetoma, pneumonia and membranoproliferative glomerulonephritis,” Journal of Clinical Microbiology, 45:2072- 2074, 2007
A37. Balak N, Silav G, Kılıç Y, Timur Ç, Elmacı İ,”Successful surgical treatment of a hemophiliac infant with nontraumatic acute subdural hematoma”, Surgical Neurology, 68,537-540, 2007
A38.Balak N, Elmacı İ,”A pioneering female neurosurgeon: Dr. Aysima Altınok”, Acta Neurochir (Wien) 149:943-948, 2007
A39. Balak N, Elmacı İ,”Costs of disorders of the brain in Europe” European Journal of Neurology, 14:2, 2007
A40. Şerefhan A, Balak N, Çerçi A, Çoşkun K, Sarı R, Silav G, Işık N, Çelik M, Elmacı İ,” Relationship between the development of vasospasm after aneurysmal subarachnoid
Haemorrhage and the levels of dendroaspis natriuretic peptide in body fluids”, Acta Neurochir Suppl 104:371-372, 2008
A41. Balak N, Çerçi A, Şerefhan A, Çoşkun K, Sarı R, Işık N, Elmacı İ,” Microsurgical treatment of unruptured intracranial aneursms”, Acta Neurochir Suppl 104:341-342, 2008
A42.Elmaci I, Balak N, “Pioneering neurosurgeon Hami Dilek and the traces of Harvey Cushing ’s legacy in his work”, J Neurosurg, 108: 821-829, 2008
A43: Işık N, Balak N, Kırcalı A, Göynümer G, Elmacı İ,”The shrinking of an anterior sacral meningocele in time following transdural ligation of its neck in a case of the currarino triad”, Turkish Neurosurgery, 18:254-258 , 2008
A44.Isik N, Balak N, Silav G, Elmaci I, “Pediatric intramedullary teratomas”, Nueropediatrics, 39:196-199,2008
A45.Balak N, ArasA, Işık N, Elmacı İ,”Making the differential diagnosis between pituitary apoplexy and craniopharyngioma”, Neurochirurgie, 15:, 2008
A46.Isik N, Elmaci I, Silav G, Celik M, Kalelioglu M,”Chiari malformation type III and results of surgery: A clinical study”, Pediatric neurosurgery, 45:19-28, 2009
A47. Balak N, Aslan B, Şerefhan A, Elmacı İ, “Intracranial retained Stone after depressed skull fracture”, Am J Forensic Med Pathol, 30. , 2009
A48. Işık N, Elmaci I, Kakşi M, Işık N, Çelik M, “Chiari malformation type I and surgical therapy”, Eurorad, 12,Nov., 2009
A49. Bozkurt SU, Ayan E, Bölükbaşı F, Elmacı İ, Pamir N, Sav A, “Immunohistochemical expression of SPARC is correlated with recurrence, survival and malignant potential in meningiomas”, APMIS 117:651-659, 2009
A50. Habesoglu TE, Balak N, Habesoglu M, Zemheri E, Işık N, Elmacı İ, Egeli E,”tracranial cholesteatoma – case report and critical review”, Clinical Neuropathology, 28:44-444, 2009
A51. Balak N, Ersoy G, Uslu Ü, Tanrıöver N, Tapul L, Çetin G, Işık N, Elmacı İ, “A microsurgical study of the occipital sinus: quantitative morphometric measurements using a novel approach”, 23:386-393, 2010
A52. Altaş M, Bayrak ÖF, Ayan E, Bölükbaşı F, Silav G, Çoşkun K, Çulha M, Şahin F, Sevli S, Elmacı İ, “The effect of polymorphism in the promoter region of the MMP-1 gene on the occurrence and invasiveness of hypophsela adenoma”, Acta Neurochir., May 4, 2010
A53. Altaş M, Bayrak OF, Çerçi A, Işık N, Çelik M, Çulha M, Şahin F, Elmacı İ, “Angiotensin converting enzyme insertion/deletion gene polymorphism in patients with familial multiple cerebral cavernous malformations”, J Clin Neurosci., May 2010
A54. Isik N, Elmaci I, Gokben B, Balak N, Tosyali N. Currarino triad: surgical management and follow-up results of four [correction of three] cases. Pediatric Neurosurg. 2010 Aug;46(2):110-9. doi: 10.1159/000319007.
A55. Gura M, Elmaci I, Sari R, Coskun N. Correlation of pulsatility index with
intracranial pressure in traumatic brain injury. Turk Neurosurg. 2011;21(2):210-5. doi: 10.5137/1019-5149.JTN.3574-10.1
A56. Isik N, Elmaci I, Kaksi M, Gokben B, Isik N, Celik M. A new entity: Chiari Zero malformation and its surgical method. Turk Neurosurg. 2011;21(2):264-8. doi:
10.5137/1019-5149.JTN.2705-09.1
A57. Silav G, Avci G, Akan M, Taylan G, Elmaci I, Akoz T. The surgical treatment
of plagiocephaly. Turk Neurosurg. 2011;21(3):304-14. doi:
10.5137/1019-5149.JTN.4095-11.1
A58. Gura M, Silav G, Isik N, Elmaci I. Noninvasive estimation of cerebral perfusion pressure with transcranial Doppler ultrasonography in traumatic brain injury. Turk Neurosurg. 2012;22(4):411-5. doi: 10.5137/1019-5149.JTN.4201-11.1.
A59. Gura M, Elmaci I, Cerci A, Sagiroglu E, Coskun KK. Haemodynamic augmentation
in the treatment of vasospasm in aneurysmal subarachnoid hemorrhage. Turk Neurosurg. 2012;22(4):435-40. doi: 10.5137/1019-5149.JTN.3863-10.1
A60. Altas M, Bayrak OF, Serefhan A, Silav G, Coskun KK, Cerci A, Isik N, Elmaci I. Investigation of ACE genome insertion/deletion correlation with immunohistochemical profile in pituitary adenomas. Turk Neurosurg. 2013;23(4):464-9. doi: 10.5137/1019-5149.JTN.7423-12.0
A61. Altas M, Serefhan A, Silav G, Cerci A, Coskun KK, Elmaci I. Diagnosis and management of pituitary abscess: a case series and review of the literature. Turk Neurosurg. 2013;23(5):611-6. doi: 10.5137/1019-5149.JTN.7443-12.2
A62. Isik N, Elmaci I, Isik N, Cerci SA, Basaran R, Gura M, Kalelioglu M. Long-term results and complications of the syringopleural shunting for treatment of syringomyelia: a clinical study. BrJ Neurosurg. 2013 Feb;27(1):91-9. doi: 10.3109/02688697.2012.703350
A63. Altaş M, Cerçi A, Silav G, Sari R, Coşkun K, Balak N, Işık N, Elmaci I. Microsurgical management of non-neurofibromatosis spinal schwannoma. Neurocirugia (Astur). 2013 Nov-Dec;24(6):244-9. doi: 10.1016/j.neucir.2012.01.002
A64. Serefhan A, Altas M, Cerci A, Isik N, Elmaci I. A new molecule in aneurysmal subarachnoid hemorrhage: dendroaspis natriuretic peptide. Turk Neurosurg. 2014;24(1):38-43. doi: 10.5137/1019-5149.JTN.8016-13.2.
A65. Efendioglu M, Basaran R, Bayrak OF, Isik N, Kaner T, Sahin F, Guclu B, Elmaci I. The role of a single nucleotide polymorphism of the matrix metalloproteinase-1 gene promoter region in invasion and prognosis of meningiomas. Turk Neurosurg. 2014;24(5):731-6. doi: 10.5137/1019-5149.JTN.9823-13.1
A66. Basaran R, Cakir FB, Isik N, Sav A, Elmaci I. Desmoplastic infantile ganglioglioma: Report of an unusual case with a cranial defect. J Pediatr Neurosci. 2014 Jan;9(1):48-51. doi: 10.4103/1817-1745.131486
A67. President O, Durdag E, Geyik S, Elmaci I. Spinal arteriovenous malformation: use
of intraoperative color Doppler ultrasound guidance for surgical resection.
case report. Med Ultrasound. 2014 Dec;16(4):386-8
A68. Silav G, Bölükbaşı FH, Özek E, Tönge M, Önöz M, Elmacı İ. A Simple Technique for Bone Storage after Decompressive Craniectomy in Children. Pediatric Neurosurg.
2015;50(3):161-4. doi: 10.1159/000381748
A69. President O, Silav G, Demirci S, Canoz O, Turanli G, Elmaci I. Focal megalencephaly: intraoperative ultrasound imaging in epilepsy surgery. J Med Ultrasound (2001). 2015 Jan;42(1):127-31. doi: 10.1007/s10396-014-0569-1
A70. Silav G, Sarı R, Bölükbaşı FH, Altaş M, Işık N, Elmacı İ. Microsurgical fenestration and cystoperitoneal shunt through preauricular subtemporal keyhole craniotomy for the treatment of symptomatic middle fossa arachnoid cysts in children. Child's Nerv Syst. 2015 Jan;31(1):87-93. doi: 10.1007/s00381-014-2530-4
A71. Onoz M, Basaran R, Gucluer B, Isik N, Kaner T, Sav A, Elmaci I. Correlation between SPARC (Osteonectin) expression with immunophenotypical and invasion characteristics of pituitary adenomas. APMI. 2015 Mar;123(3):199-204. doi: 10.1111/apm.12342
A72. Baskan O, Silav G, Sari R, Canoz O, Elmaci I. Relationship of intraoperative ultrasound characteristics with pathological grades and Ki-67 proliferation index in intracranial gliomas. J Med Ultrasound (2001). 2015 Apr;42(2):231-7. doi: 10.1007/s10396-014-0593-1
A73. Aras AB, Guven M, Balak N, Ayan E, Uyar SB, Elmaci I. Evaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Disease. Turk Neurosurg. 2016;26(2):274-9. doi: 10.5137/1019-5149.JTN.12762-14.0
A74. Elmaci İ, Altinoz MA, Sav A, Yazici Z, Ozpinar A. Giving another chance to mifepristone in pharmacotherapy for aggressive meningiomas-A likely synergism with hydroxyurea? Curr Proble Cancer. 2016 Sep - Dec;40(5-6):229-243. doi: 10.1016/j.currproblcancer.2016.05.001
A75. Baskan O, Silav G, Bolukbasi FH, Canoz O, Geyik S, Elmaci I. Relation of apparent diffusion coefficient with Ki-67 proliferation index in meningiomas. BrJ Radiol. 2016;89(1057):20140842. doi: 10.1259/bjr.20140842
A76. Altinoz MA, Elmaci I, Ince B, Ozpinar A, Sav AM. Hemoglobins, Hemorphins, and 11p15.5 Chromosomal Region in Cancer Biology and Immunity with Special Emphasis for Brain Tumors. J Neurol Surg A Cent Eur Neurosurg. 2016 May;77(3):247-57. doi: 10.1055/s-0035-1566120
A77. Kırcelli A, Özel Ö, Can H, Sarı R, Cansever T, Elmacı İ. Is the presence of linear fracture a predictor of delayed posterior fossa epidural hematoma? Ulus Journal of Trauma Emergency Surgery. 2016 Jul;22(4):355-60. doi: 10.5505/tjtes.2015.52563
A78. Basaran R, Uslu S, Gucluer B, Onoz M, Isik N, Tiryaki M, Yakicier C, Sav A, Elmaci I. Impact of 1p/19q codeletion on the diagnosis and prognosis of different grades of meningioma. BrJ Neurosurg. 2016 Oct;30(5):571-6. doi: 10.1080/02688697.2016.1181155
A79. Elmaci I, Altinoz MA. Thymoquinone: An edible redox-active quinone for the pharmacotherapy of neurodegenerative conditions and glial brain tumors. A short review. Biomed Pharmacother. 2016 Oct;83:635-640. doi: 10.1016/j.biopha.2016.07.018
A80. Elmaci İ, Altinoz MA. A Metabolic Inhibitory Cocktail for Grave Cancers: Metformin, Pioglitazone and Lithium Combination in Treatment of Pancreatic Cancer and Glioblastoma Multiforme. Biochem Genet. 2016 Oct;54(5):573-618. doi: 10.1007/s10528-016-9754-9
A81. Sari R, Tonge M, Bolukbasi FH, Onoz M, President O, Silav G, Elmaci I. Management of Failed Cranioplasty. Turk Neurosurg. 2017;27(2):201-207. doi: 10.5137/1019-5149.JTN.15395-15.0
A82. Taskiran E, Brandmeier S, Ozek E, Sari R, Bolukbasi F, Elmaci I. Multimodal Intraoperative Neurophysiological Monitoring in Spinal Cord Surgery. Turk Neurosurg. 2017;27(3):436-440. doi: 10.5137/1019-5149.JTN.16414-15.1
A83. Elmaci İ, Altinoz MA. Recrudescence of herpes virus infections following resection of schwannomas. An antiviral role of merlin? Med Hypotheses. 2017; 102:128-129. doi: 10.1016/j.mehy.2017.03.024
A84. Altinoz MA, Guloksuz S, Elmaci I. Rabies virus vaccine as an immune adjuvant against cancers and glioblastoma: new studies may resurrect a neglected potential. Clin Transl Oncol. 2017 Jul;19(7):785-792. doi: 10.1007/s12094-017-1613-6
A85. Altinoz MA, Elmaci I, Bolukbasi FH, Ekmekci CG, Yenmis G, Sari R, Sav A. MGMT gene variants, myelotoxicity and glioma risk in temozolomide. A concise literature survey including an illustrative case. J Chemother. 2017 Aug;29(4):238-244. doi: 10.1080/1120009X.2017.1312752
A86. Elmaci İ, Altinoz MA, Bolukbasi FH, Yapicier O, Sav A. Paradoxical results obtained with Ki67-labeling and PHH3-mitosis index in glial tumors: a literature analysis. Clin Neuropathol. 2017 Nov/Dec;36(6):272-282. doi: 10.5414/NP301028
A87. Elmaci İ, Altinoz MA, Sav A, Bolukbaşı FH, Önöz M, President Ö, Sari R. Whorling-sclerosing meningioma. A review on the histological features of a rare tumor including an illustrative case. Clin Neurol Neurosurg. 2017 Nov;162:85-90. doi: 10.1016/j.clineuro.2017.09.09
A88. Brandmeier S, Taskiran E, Bolukbasi FH, Sari R, Elmaci I. Multimodal Intraoperative Neurophysiological Monitoring in Neurosurgical Oncology. Turk Neurosurg. 2018;28(2):204-210. doi: 10.5137/1019-5149.JTN.19177-16.1
A89. Elmaci İ, Altinoz MA, Sari R. Immune Pathobiology of Schwannomas: A Concise
review. J Neurol Surg A Cent Eur Neurosurg. 2018 Mar;79(2):159-162. doi:
10.1055/s-0037-1603949
A90. Altinoz MA, Ozpinar A, Alturfan EE, Elmaci I. Vinorelbine's anti-tumor actions may depend on the mitotic apoptosis, autophagy and inflammation: hypotheses with implications for chemo-immunotherapy of advanced cancers and pediatric gliomas. J Chemother. 2018 Jul;30(4):203-212. doi: 10.1080/1120009X.2018.1487149
A91. Elmaci I, Altinoz MA. Targeting the cellular schizophrenia. Likely employment of the antipsychotic agent pimozide in treatment of refractory cancers and glioblastoma. Crit Rev Oncol Hematol. 2018 Aug;128:96-109. doi: 10.1016/j.critrevonc.2018.06.004
A92. Altinoz MA, Elmaci I, Cengiz S, Retired-Alturfan E, Ozpinar A. From epidemiology to treatment: Aspirin's prevention of brain and breast-cancer and cardioprotection may associate with its metabolite gentic acid. Chem Biol Interact. 2018 Aug 1;291:29-39. doi: 10.1016/j.cbi.2018.05.016
A93. Altinoz MA, Elmaci I. Targeting nitric oxide and NMDA receptor-associated pathways in treatment of high grade glial tumors. Hypotheses for nitro-memantine and nitrones. Nitric Oxide. 2018 Sep 1;79:68-83. doi: 10.1016/j.niox.2017.10.001
A94. Elmaci İ, Alturfan EE, Cengiz S, Ozpinar A, Altinoz MA. Neuroprotective and tumoricidal activities of cardiac glycosides. Could oleandrin be a new weapon against stroke and glioblastoma? IntJ Neurosci. 2018 Sep;128(9):865-877. doi: 10.1080/00207454.2018.1435540
A95. Altinoz MA, Nalbantoglu J, Ozpinar A, Emin Ozcan M, Del Maestro RF, Elmaci I. From epidemiology and neurodevelopment to antineoplasticity. Medroxyprogesterone reduces human glial tumor growth in vitro and C6 glioma in rat brain in vivo. Clin Neurol Neurosurg. 2018 Oct;173:20-30. doi: 10.1016/j.clineuro.2018.07.012
A96. Lowerinoz MA, Bilir A, Elmaci İ. Erucic acid, a component of Lorenzo's oil and PPAR-δ ligand modifies C6 glioma growth and toxicity of doxorubicin. Experimental data and a comprehensive literature analysis. Chem Biol Interact. 2018 Oct 1;294:107-117. doi: 10.1016/j.cbi.2018.08.024
A97. Elmaci İ, Altinoz MA, Sari R, Bolukbasi FH. Phosphorylated Histone H3 (PHH3) as a Novel Cell Proliferation Marker and Prognosticator for Meningeal Tumors: A Short Review. Appl Immunohistochem Mol Morphol. 2018 Oct;26(9):627-631. doi: 10.1097/PAI.0000000000000499
A98. Elmaci İ, Ozpinar A, Bilir A, Altinoz MA. Medroxyprogesterone effects on colony growth, autophagy and mitochondria of C6 glioma cells are augmented with tibolone and temozolomide: Cell kinetic and electron microscopical studies with a broad review of the literature. Clin Neurol Neurosurg. 2019 Feb;177:77-85. doi: 10.1016/j.clineuro.2018.12.022
A99. Altinoz MA, Ozpinar A, Ozpinar A, Perez JL, Elmaci İ. Methenamine's journey of
160 years: Repurposal of an old urinary antiseptic for treatment and hypoxic radiosensitization of cancers and glioblastoma. Clin Exp Pharmacol Physiol. 2019 May;46(5):407-412. doi: 10.1111/1440-1681.13070
A100. Altinoz MA, Ozpinar A, Elmaci I. Reproductive epidemiology of glial tumors may
reveal novel treatments: high-dose progestins or progesterone antagonists as endocrino-immune modifiers against glioma. Neurosurg Rev. 2019 Jun;42(2):351-369.
doi: 10.1007/s10143-018-0953-1
A101. Elmaci I, Ozpinar A, Ozpinar A, Perez JL, Altinoz MA. From epidemiology and
neurometabolism to treatment: Vitamin D in pathogenesis of glioblastoma Multiforme (GBM) and a proposal for Vitamin D + all-trans retinoic acid + Temozolomide combination in treatment of GBM. Metab Brain Dis. 2019 Jun;34(3):687-704. doi: 10.1007/s11011-019-00412-5
A102. Elmaci İ, Bilir A, Ozpinar A, Altinoz MA. Gemcitabine, vinorelbine and cyclooxygenase inhibitors in the treatment of glioblastoma. Ultrastructural analysis in C6 glioma in vitro. Tissue Cell. 2019 Aug;59:18-32. doi: 10.1016/j.tice.2019.05.008
A103. Altinoz MA, Topcu G, Hacimuftuoglu A, Ozpinar A, Ozpinar A, Hacker E, Elmaci İ. Noscapine, a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma. Neurochem Res. 2019 Aug;44(8):1796-1806. doi: 10.1007/s11064-019-02837-x
A104. Altinoz MA, Ozpinar A, Ozpinar A, Hacker E, Elmaci İ. Could hepatitis B vaccine act as an adjuvant to lower risk and relapses of cancer? Clin Exp Pharmacol Physiol. 2019 Aug;46(8):694-704. doi: 10.1111/1440-1681.13096
A105. Altinoz MA, Topcu G, Elmaci İ. Boron's neurophysiological effects and tumoricidal activity on glioblastoma cells with implications for clinical treatment. IntJ Neurosci. 2019 Oct;129(10):963-977. doi: 10.1080/00207454.2019.1595618
A106. Altinoz MA, Ozpinar A, Ozpinar A, Hacker E, Elmaci İ. Hypothesis: Could Hepatitis B vaccine act as an immune adjuvant in glioblastoma? Clues to conduct further epidemiological analyzes. Int Immunopharmacol. 2020 Apr;106038. doi:
10.1016/j.intimp.2019.106038
A107. Ünal İ, Çalışkan-Ak E, Üstündağ ÜV, Ateş PS, Alturfan AA, Altinoz MA, Elmaci I, Emekli-Alturfan E. Neuroprotective effects of mitoquinone and oleandrin on Parkinson's disease model in zebrafish. IntJ Neurosci. 2020 Jun 130;(6):574-58 doi: 10.1080/00207454.2019.1698567
A108.Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish.
Eğmezer G, Üstündağ ÜV, Ateş PS, Ünal I, Üstündağ FD, Alturfan AA, Retired-Alturfan E, Altinoz MA, Elmaci I.
HumExp Toxicol. 2020 Jul;39(7):920-929. doi: 10.1177/0960327120905961. Epub 2020 Feb 13.
PMID: 32054343
A109. Benign leiomyoma with multiple metastases to vertebrae and calvarium: An index case with comprehensive review of endocrine targets.
Elmaci İ, Altinoz MA, Ozlu BEK, Sari R, Er O, Danyeli AE, Karaarslan E.
Neurosurg Rev. 2021 Feb;44(1):289-300. doi: 10.1007/s10143-020-01268-5. Epub 2020 Feb 20.
PMID: 32078084 Review.
A110 Could isthmic approach to far lateral disc hernias cause instability?
Sari R, Elibol FKE, Özlü EBK, Elmacı İ, Demir T.
Clin Biomech (Bristol, Avon). 2020 Jun;76:150004. doi: 10.1016/j.clinbiomech.2020.105004. Epub 2020 Apr 20. PMID: 32388076
A111. Treatment Strategies for Dopamine Agonist-Resistant and Aggressive Prolactinomas: A Comprehensive Analysis of the Literature.
Sari R, Altinoz MA, Ozlu EBK, Sav A, Danyeli AE, Chairman O, Er O, Elmaci I.
Horm Metab Res. 2021 Jul;53(7):413-424. doi: 10.1055/a-1525-2131. Epub 2021 Jul 19.
PMID: 34282593
A112. A pediatric cerebral tumor with MN1 alteration and pathological features mimicking carcinoma metastasis: may the terminology "high grade neuroepithelial tumor with MN1 alteration" still be relevant?
Sari R, Altinoz MA, Ozyar E, Danyeli AE, Elmaci I.
Child's Nerv Syst. 2021 Jul 16. doi: 10.1007/s00381-021-05289-3. Online ahead of print.
PMID: 34269865 Review.
A113. Caprylic acid ameliorates rotenone induced inflammation and oxidative stress inthe gut-brain axis in Zebrafish.
Cansız D, Ünal İ, Üstündağ ÜV, Alturfan AA, Altinoz MA, Elmacı İ, Retired-Alturfan E.
Mol Biol Rep. 2021 Jun;48(6):5259-5273. doi: 10.1007/s11033-021-06532-5. Epub 2021 Jul 6.
PMID: 34228274
A 114. Polymorphous low-grade neuroepithelial tumor of the young: A detailed pathomolecular analysis and discussion of a case.
Danyeli AE, Altinoz MA, Sari R, Elmaci I.
Clin Neuropathol. 2021 Sep-Oct;40(5):271-278. doi: 10.5414/NP301370.
PMID: 33860759
A 115. Effect of three post-harvest methods and roasting degree on sensory profile of Turkish coffee assessed by Turkish and Brazilian panelists.
Elmaci I, Gok I.
J Sci Food Agric. 2021 Oct;101(13):5368-5377. doi: 10.1002/jsfa.11185. Epub 2021 Mar 16.
PMID: 33650176
A 116. Shall elective neurosurgical patients be postponed during a pandemic? Lessons from the peak period of COVID-19 pandemic.
Elmaci I, Altinoz MA, Sari R, Syed HR, Aydinlar EI, Kahraman S, Jean WC.
J Neurosurg Sci. 2021 Aug;65(4):460-461. doi: 10.23736/S0390-5616.20.05230-3. Epub 2020 Dec 15.
PMID: 33320470 Free article. No abstract available.
A 117. Neurosurgical and neuro-immunological management of IgG4-related hypertrophic sclerosing pachymeningitis. A literature survey and discussion of a unique index case.
Elmaci I, Altinoz MA, Akdemir G, Sari R, Chairman O, Ozpinar A, Hacker E, Sav A.
Clin Neurol Neurosurg. 2021 Jan;200:106342. doi: 10.1016/j.clineuro.2020.106342. Epub 2020 Nov 1.
PMID: 33158629 Review
A 118. Intraoperative Neuromonitoring of Blink Reflex During Posterior Fossa Surgeries and its Correlation With Clinical Outcome.
Aydınlar EI, Kocak M, Soykam HO, Mat B, Dikmen PY, Sezerman OU, Elmaci İ, Pamir MN.
JClin Neurophysiol. 2020 Sep 28. doi: 10.1097/WNP.0000000000000777. Online ahead of print.
PMID: 33009043
A 119. PPARδ and its ligand erucic acid may act anti-tumoral, neuroprotective, and myelin protective in neuroblastoma, glioblastoma, and Parkinson's disease.
Altinoz MA, Elmaci İ, Hacimuftuoglu A, Ozpinar A, Hacker E, Ozpinar A.
Mol Aspects Med. 2021 Apr;78:100871. doi: 10.1016/j.mam.2020.100871. Epub 2020 Jul 20.
PMID: 32703610 Review.
A 119. Progesterone at high doses reduces the growth of U87 and A172 glioblastoma cells: Proteomic changes regarding metabolism and immunity.
Altinoz MA, Ucal Y, Yilmaz MC, Kiris İ, Ozisik O, Sezerman U, Ozpinar A, Elmaci İ.
Cancer Med. 2020 Aug;9(16):5767-5780. doi: 10.1002/cam4.3223. Epub 2020 Jun 26.
PMID: 32590878 Free PMC article.
A 120. Decompressive craniectomy in traumatic brain injury: Transcranial Doppler sonography used as a guide.
Sarı R, Bolukbasi FH, Kahraman Özlü EB, Isik N, Güra Çelik M, Elmacı İ.
Ulus Journal of Trauma Emergency Surgery. 2020 May;26(3):418-424. doi: 10.14744/tjtes.2020.04640.
PMID: 32436966 Free article. English.

D. Articles published in national peer-reviewed journals:
D1. Ataklı D, Elmacı İ, Özdemir F, Arpacı B, Forta H, Ataklı C, “Progressive multiphacal leukoencephalopathy”, Şişli Etfal Hospital Bulletin, 3:417-428 (1990).
D2. Özer F, Elmacı İ, Aysal F, Ataklı D, Arpacı B, “Spontaneous intracerebral hematoma: analysis of 177 cases”, Fikiren Adam, 3:64-70 (1991).
D3. Bilgic S, Ilaslan H, Yuyerrdurmaz M, Elmaci I, Balak N, Oral Z, “Primary cerebral lymphoma”, Fikiren Adam, 1:33-35 (1991).
D4. Bilgiç S, Oral Z, Elmacı İ, İlaslan H, Karakuş A, “Supratentorial suboccipital subdural
haematoma: A case report”, Turkish Neurosurgery, 2:160-161 (1992).
D5. Özer F, Ataklı D, Elmacı İ, Albayrak S, Yalçıner B, Forta H, Arpacı B, “Neuroophthalmological findings in thalamic hematomas”, Fikiren Adam, 6:59-63 (1993).
D6. Bilgiç S, Elmacı İ, Karakaya B, Kuru Ş, Oral Z, “Tension pneumocephalus and acute subarachnoid haemorrhage following treatment of chronic subdural haematoma: A case report”, Turkish Neurosurgery, 3:34-36 (1993).
D7. Ermiş İ, Hayirlıoğlu T, Canbolat A, Arıncı A, Elmacı İ, “Fronto-ethmoidal meningoencephalocele: A case report”, Fikiren Adam, 8(2):56-59 (1995).
D8. Ermiş İ, Arıncı A, Elmacı İ, Hayırlıoğlu T, Oral Z, “The treatment of craniofacial meningioma”, Fikiren Adam, 8(2):61-64 (1995).
D9. Elmacı İ, Arslan B, Tutkan İ, Karakaya B, Oral Z, “Hydatid Spinal Cyst: Case Report”
The Thinker, 10(1):62-64 (1997).
D10. Ratip S, Budak-Alpdoğan T, Alpdoğan Ö, Çetiner M, Kart S, Elmacı İ, Bayık M,
Normal pressure hydrocephalus associated with chronic alpha interferon treatment. A case report”, Turkish Journal of Haematology, 17(1):33-35 (2000).
D11. Dağçınar A, Elmacı İ, Özgen S, Bayri Y, Özek MM, Pamir MN, “Intraventricular meningiomas”, Turkish Journal of Neurosurgery 10:144-150, (2000).
D12. Elmacı İ, Adam B, Özgen S, Pamir MN, “Lipoma and incomplete agenesis of the corpus callosum associated with arachnoid cyst located in the temporal pole: case report”,
Marmara Medical Journal 14(1):31-34 (2001).
D13. Ekinci G, Baltacıoğlu F, Elmacı İ, Pamir MN, Erzen C, “Dynamic MR imaging in the detection of pituitary microadenoma”, Marmara Medical Journal 14(1):23-26 (2001).
D14. Elmacı İ, Kurtkaya Ö, Sav A, Pamir MN, “"Proliferating" sCentral neurocytoma: case report”, Turkish Journal of Pathology 16:97-99 (2000).
D15. Kılıç T, Elmacı İ, Pamir MN, “Carotid endarterectomy: indications, monitoring, complications and surgical technique”, Turkish Journal of Neurosurgery 11:1-14 (2001).
D16. Elmacı İ, Kemerdere R, Ekinci G, Özgen S, Pamir MN, “Suprasellar arachnoid cyst presenting with amenorrhoea and galactorrhoea,” Turkish Neurosurgery, 11:134-137 (2001).
D17. Elmacı İ, Gürses İ, Kurtkaya Ö, Sav A, Pamir MN, “Astroblastoma: case report”,
Turkish Journal of Pathology 17:46-48 (2001).
D18. Elmacı İ, Tuncer N, Aktan S, Pamir MN, “Decompressive craniectomy application in acute ischemic stroke”, Turkish Journal of Neurology 7:9-18 (2001).
D19. Elmacı İ,”Rudolph Nissen” (Letter to the Editor), Journal of Neurological Sciences (NOROL BIL D), 18:4, (2001).
D20. Ustalar S, Elmacı İ, Lim S, Özgen S, Göğüş Y, Pamir MN, “Mayfield head rest and epidural hematoma”, Journal of Neurological Sciences (NOROL BIL D), 18:4, (2001).
D21. Elmacı İ, Bayraklı F, Kurtkaya Ö, Peker S, Sav A, Pamir MN, “Cerebellar ganglioglioma in an adult patient: A case report”, Turkish Journal of Pathology 17:81-84, (2001)
D22. Dağçınar A, Özek MM, Karabağlı H, Kılıç T, Elmacı İ, Sav A, Pamir MN,
“Tumors of the choroid plexus” Turkish Neurosurgery (In Press)
D23. Kurtkaya Ö, Elmacı İ, Ömeroğlu E, Sav A, Pamir MN, “Correlation of histomorphologic, histochemical and immunophenotypic findings in pituitary adenomas showing prolactin activity,” Turkish Neurosurgery 12:74-80, (2002)
D24.Elmacı İ, “Hami Dilek and Peripheral Nerve Surgery,” Bulletin of Spinal and Peripheral Nerve Surgery 27:11-12, 2005
D25.Gül M, Bölükbaşı FH, Sözenoğlu İ, Işık N, Çelik M, Elmacı İ, “Chronic subdural hematoma developing after spinal anesthesia”, Turkish Journal of Neurosurgery, 3:177-181, 2007
D26. Elmacı İ, Ayan E, “Falks meningiomas”, Turkey Clinics J Surg Med Sci, 3:96-98, 2007
D27. Sarı R, Çerçi A, Işık N, Elmacı İ, “Spontaneous regression in carotid stenosis under antiaggregant therapy”, Turkish Journal of Cerebrovascular Diseases, 14:19-20, 2008
D28. Çakmak MAU, Işık N, Cantürk İ, Sarı R, Yıldız N, Candan F, Işık N, Elmacı İ, “Subarachnoidal hemorrhages 105 case reports”, Journal of Neurological Sciences, 15:163-168, 2008
D29. Tuncer N, Elmacı İ, Afşar N, Aktan S, Pamir N, “Decompressive surgery in acute ischemic stroke”, Journal of Nervous System Surgery, 1:20-25, 2008
D30. Çelik M, Koltka EN, Elmacı İ, Silav G, “Cervical neurofibromatosis and anesthesia”, Turkey Clinics, Anesthesiology Reanimation, 7:179-182, 2009
D31. Budakçı T, Koltka EN, Sağıroğlu E, Elmacı İ, Çelik M, “Effects of Esmolol infusion in Craniotomies”, Türk Anest Rean Der Dergisi, 38:35-44, 2010
  • Turkish Medical Association
  • Turkish Neurosurgery Association
  • Brain Research Association
  • Turkish Cerebrovascular Diseases Association
  • Skull Base Association
  • European Society of Neurooncology (EANO)
  • Europian Skull Base Society
Awards and Documents:

1st Turkish Neurosurgery Association Appreciation Award
Neurosurgery Congress 22-26 May 2001, Antalya
Award-winning work:
Dr. Hami Wish. A pioneer in neurosurgery, Marmara Neurological Sciences Foundation Publication, Asır Press, Istanbul 2001, 360 pages (ISBN 975-94434-6-5)
2. “Doctor of the Year” Award
Marmara University Hospital Nursing Services Directorate
12-18 May Nursing Week, 14 May 2002, Istanbul
3. Marmara University Faculty of Medicine Award for Academician with the Most Publishing Abroad in 2002
Academic Committee, 28 June 2002, Haydarpaşa- Istanbul
4. Turkish Neurosurgery Society 2003 Scientific Research Award
Neurosurgery Congress 20-24 May 2003, Antalya
Award-winning work:
Elmacı İ, Kurtkaya Ö, Ercan F, Tuncer N, Bakırcı N, San T, Sav A, Pamir MN, Tanrısever E, “The effects of quantum energy surgical device and of bipolar coagulation: A comparative experimental study,” Acta Neurochirurgica (Wien ), 144:377-383 (2002).
5. Marmara University Outstanding Achievement Award
Considering the international publications he made in 2000,
6. Marmara University Scientific Research Projects Commission Incentive and Support Award
Considering his publications in 2001
7. EONA (The European Association for Neurooncology) Poster Award
7th Congress of the European Association of Neurooncology,
September 14-17, 2006, Vienna, Austria
Award-winning work:
Falx meningiomas: clinical and radiological analysis and surgical approaches
Ayan E, Aras A, Silav G, Coşkun K, Çerçi A, Balak N, Işık N, Devrim S, Çelik M, Elmacı İ
8. Turkish Neurosurgery Association, 7th prize in the evaluation of the 2007 reports of the year
Neurosurgery Congress 20-24 April 2007, Antalya
Award-winning work:
Altaş M, Çerç A, Bayrak ÖF, Işık N, Çulha M, Şahin F, Çelik M, Elmacı İ
Angiotensin-converting enzyme (ACE) gene insertion-deletion polymorphism in patients with multiple familial cerebral cavernous malformations
9. Health Dept. Certificate of appreciation 13.03.2007/0296
“For the effort shown in the post and for the valuable contribution to health services”
10 Istanbul Governorship Certificate of Appreciation 11.03.2008/404
“For the effort shown in the post and for the valuable contribution to health services”
11. Ministry of Health Göztepe Training and Research Hospital Chief Physician certificate of appreciation
"one. For contributions to the Pediatric Emergency and Intensive Care Nursing Symposium, 17 October 2008
12. Certificate of appreciation from “United Nations Association of Afghanistan”, 2008
13. Göztepe Training and Research Hospital Neurosurgery Clinic EANS (European Neurosurgery Association) Accreditation, 6 April, 2009

Ask Liv Expert