Prof. MD.
Tahsin Yakut
Genetic
Interests
• Clinical Genetics
• Genetic Analyses in Recurrent Miscarriages and Risky Pregnancies
• Genetic Diagnosis and Screening in IVF Treatments
• Infertility
• Genetic Typing for Smart Drug Therapy in Cancer
Education:
• 1989 - Uludag University, Faculty of Medicine - Medicine Education
• 2002 - Uludag University, Faculty of Medicine - Medical Genetics Department Residency Training
• 2006 - Uludag University, Faculty of Medicine - Medical Genetics Department - Asst. Prof. Dr.
• 2006 - Uludag University, Faculty of Medicine - Medical Genetics Department - Assoc. Prof. Dr.
• 2012 - Uludag University, Faculty of Medicine - Medical Genetics Department - Prof. Dr.
Experience:
• Uludag University, Faculty of Medicine, Medical Genetics Department
• George-Agust University, Molecular Genetics Department
• Innova Medicine - Sherr Institute, United States of America
• Queen Elizabeth Hospital - Molecular Cytogenetics Department, England
• Private Jimer Hospital
• Istinye University Genetic Diagnosis Center
• 1989 - Uludag University, Faculty of Medicine - Medicine Education
• 2002 - Uludag University, Faculty of Medicine - Medical Genetics Department Residency Training
• 2006 - Uludag University, Faculty of Medicine - Medical Genetics Department - Asst. Prof. Dr.
• 2006 - Uludag University, Faculty of Medicine - Medical Genetics Department - Assoc. Prof. Dr.
• 2012 - Uludag University, Faculty of Medicine - Medical Genetics Department - Prof. Dr.
Experience:
• Uludag University, Faculty of Medicine, Medical Genetics Department
• George-Agust University, Molecular Genetics Department
• Innova Medicine - Sherr Institute, United States of America
• Queen Elizabeth Hospital - Molecular Cytogenetics Department, England
• Private Jimer Hospital
• Istinye University Genetic Diagnosis Center
Publications: (83)
1-Evaluation of relationship between chromosome 22 and p53 gene alterations and the subtype of men-ingiomas by the interphase-FISH technique.
Yakut T, Bekar A, Doygun M, Acar H, Egeli U, Ogul E.Teratog Carcinog Mutagen. 2002;22(3):217-25. doi: 10.1002/tcm.10013.PMID: 11948632
2-Comparison of genetic changes between interphase and metaphase nuclei in monitoring CML and APL treatment using DC-FISH technique.
Yakut T, Ali R, Egeli U, Ozkalemkas F, Ercan I, Ozçelik T, Ozkocaman V, Yigit B, Tunali A.Cancer Biol Ther. 2004 Sep;3(9):858-63. doi: 10.4161/cbt.3.9.1039. Epub 2004 Sep 18.PMID: 15254420
3-Investigation of c-myc and p53 gene alterations in the tumor and surgical borderline tissues of NSCLC and effects on clinicopathologic behavior: by the FISH technique.
Yakut T, Egeli U, Gebitekin C.Lung. 2003;181(5):245-58. doi: 10.1007/s00408-003-1026-x.PMID: 14705768
Cite
4-Toll-like receptor-9 gene polymorphism in common variable immunodeficiency.
Tanir S, Karkucak M, Yakut T, Kilic SS.J Investig Allergol Clin Immunol. 2010;20(3):267-8.PMID: 20635795 Free article. No abstract available.
5-Genes that Affect Brain Structure and Function Identified by Rare Variant Analyses of Mendelian Neuro-logic Disease.
Karaca E, Harel T, Pehlivan D, Jhangiani SN, Gambin T, Coban Akdemir Z, Gonzaga-Jauregui C, Erdin S, Bayram Y, Campbell IM, Hunter JV, Atik MM, Van Esch H, Yuan B, Wiszniewski W, Isikay S, Yesil G, Yuregir OO, Tug Bozdogan S, Aslan H, Aydin H, Tos T, Aksoy A, De Vivo DC, Jain P, Geckinli BB, Sezer O, Gul D, Durmaz B, Cogulu O, Ozkinay F, Topcu V, Candan S, Cebi AH, Ikbal M, Yilmaz Gulec E, Gezdirici A, Koparir E, Ekici F, Coskun S, Cicek S, Karaer K, Koparir A, Duz MB, Kirat E, Fenercioglu E, Ulucan H, Seven M, Guran T, Elcioglu N, Yildirim MS, Aktas D, Alikaşifoğlu M, Ture M, Yakut T, Overton JD, Yuksel A, Ozen M, Muzny DM, Adams DR, Boerwinkle E, Chung WK, Gibbs RA, Lupski JR.Neuron. 2015 Nov 4;88(3):499-513. doi: 10.1016/j.neuron.2015.09.048.PMID: 26539891 Free PMC article.
6-A fertile patient with 45X/47XXX mosaicism.
Sahinturk S, Ozemri Sag S, Ture M, Gorukmez O, Topak A, Yakut T, Gulten T.Genet Couns. 2015;26(1):29-34.PMID: 26043504
Cite
7-De novo partial trisomy distal 4q: a case report.
Gorukmez O, Sag SO, Gorukmez O, Ture M, Gulten T, Yakut T.Genet Couns. 2014;25(4):423-8.PMID: 25804022
8-MMP2 gene-735 C/T and MMP9 gene -1562 C/T polymorphisms in JAK2V617F positive myeloprolifera-tive disorders.
Sag SO, Gorukmez O, Ture M, Gorukmez O, Topak A, Sahinturk S, Ocakoglu G, Gulten T, Ali R, Yakut T.Asian Pac J Cancer Prev. 2015;16(2):443-9. doi: 10.7314/apjcp.2015.16.2.443.PMID: 25684469 Free ar-ticle.
9-Dyskeratosis Congenita: A Case Report.
Ozemri Sag S, Topak A, Gorukmez O, Gorukmez O, Ture M, Carrillo J, Sahinturk S, Gulten T, Perona R, Yakut T.Genet Couns. 2016;27(2):263-7.PMID: 29485835 No abstract available.
10-Meiotic segregation analysis of reciprocal translocations both in sperms and blastomeres.
Yakut T, Ercelen N, Acar H, Kimya Y, Egeli U.Am J Med Genet A. 2006 May 15;140(10):1074-82. doi: 10.1002/ajmg.a.31215.PMID: 16596678
11-Association and Prognostic Significance of the Functional -1562C/T Polymorphism in the Promoter Region of MMP-9 in Turkish Patients with Gastric Cancer.
Avcı N, Ture M, Deligonul A, Cubukcu E, Olmez OF, Sahinturk S, Topak A, Kurt E, Evrensel T, Şahin AB, Yakut T.Pathol Oncol Res. 2015 Sep;21(4):1243-7. doi: 10.1007/s12253-015-9950-7. Epub 2015 Jul 9.PMID: 26156886
12-GSTT1 and GSTM1 gene polymorphisims in sarcoidosis.
Coskun F, Karkucak M, Yilmaz D, Yakut T, Uzaslan E.Sarcoidosis Vasc Diffuse Lung Dis. 2016 Oct 7;33(3):253-257.PMID: 27758991
13-Delayed Puberty and Gonadal Failure in Patients with HAX1 Mutation.
Cekic S, Saglam H, Gorukmez O, Yakut T, Tarim O, Kilic SS.J Clin Immunol. 2017 Aug;37(6):524-528. doi: 10.1007/s10875-017-0412-8. Epub 2017 Jul 5.PMID: 28681255
14-Investigation of MEFV gene polymorphisms (G138G and A165A) in adult patients with familial Medi-terranean fever.
Öksuz MF, Karkucak M, Görukmez O, Ocakoğlu G, Yıldız A, Ture M, Yakut T, Dilek K.Rev Bras Reumatol Engl Ed. 2017 Nov-Dec;57(6):501-506. doi: 10.1016/j.rbre.2016.02.004. Epub 2016 Mar 10.PMID: 29173686 Free article. English, Portuguese.
15-TURNER SYNDROME WITH 45,X/46,X,I(Xq)/47,X,I(Xq),I(Xq) KARYOTYPE.
Gorukmez O, Sag SO, Gulten T, Gorukmez, Ture M, Yakut T.Genet Couns. 2015;26(2):267-9.PMID: 26349201 No abstract available.
16-Associations analysis of GSTM1, T1 and P1 Ile105Val polymorphisms with carpal tunnel syndrome.
Eroğlu P, Erkol İnal E, Sağ ŞÖ, Görükmez Ö, Topak A, Yakut T.Clin Rheumatol. 2016 May;35(5):1245-51. doi: 10.1007/s10067-014-2855-0. Epub 2015 Jan 9.PMID: 25566970
17-Association of GSTM1, GSTT1, GSTP1-ILE105VAL and ACE I/D polymorphisms with ankylosing spondyli-tis.
İnal EE, Görükmez O, Eroğlu S, Görükmez Ö, Solak Ö, Topak A, Yakut T.Rheumatol Int. 2016 Jan;36(1):17-23. doi: 10.1007/s00296-015-3317-y. Epub 2015 Jul 18.PMID: 26186891
18-Evaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosis.
Ceylan E, Karkucak M, Coban H, Karadag M, Yakut T.J Infect Public Health. 2017 Nov-Dec;10(6):774-777. doi: 10.1016/j.jiph.2016.11.003. Epub 2017 Feb 8.PMID: 28189510 Free article.
19-Association between the catechol-o-methyltransferase val158met polymorphism with susceptibility and severity of carpal tunnel syndrome.
Erkol İnal E, Eroğlu P, Görükmez O, Özemri Sağ Ş, Yakut T.Balkan J Med Genet. 2016 Jul 9;18(2):43-48. doi: 10.1515/bjmg-2015-0085. eCollection 2015 Dec 1.PMID: 27785396 Free PMC article.
20-Distribution of KRAS and BRAF Mutations in Metastatic Colorectal Cancers in Turkish Patients.
Gorukmez O, Yakut T, Gorukmez O, Sag SO, Karkucak M, Kanat O.Asian Pac J Cancer Prev. 2016;17(3):1175-9. doi: 10.7314/apjcp.2016.17.3.1175.PMID: 27039744 Free article.
21-CLINICAL EFFECT OF A MUTATION (p.Glu322Asp, c.966 G>T) IN PANK2 GENE IN A FAMILY WITH ATYP-ICAL PANTOTHENATE KINASE-ASSOCIATED NEURODEGENERATION.
Ayas ZO, Karkucak M, Ocal RO, Yakut T.Genet Couns. 2016;27(4):489-494.PMID: 30226968
22-Glutathione S-transferase T1, M1 and P1 Genetic Polymorphisms and Susceptibility to Colorectal Can-cer in Turkey.
Gorukmez O, Yakut T, Gorukmez O, Sag SO, Topak A, Sahinturk S, Kanat O.Asian Pac J Cancer Prev. 2016;17(8):3855-9.PMID: 27644629 Free article.
23-Glutathione S-Transferase M1 and T1 Gene Polymorphisms in Patients with Chronic Plaque-Type Pso-riasis: A Case-Control Study.
Solak B, Karkucak M, Turan H, Ocakoğlu G, Özemri Sağ Ş, Uslu E, Yakut T, Erdem T.Med Princ Pract. 2016;25(2):155-8. doi: 10.1159/000442165. Epub 2015 Nov 4.PMID: 26535568 Free PMC article.
24Spectrum of EGFR gene mutations and ALK rearrangements in lung cancer patients in Turkey.
Sag SO, Gorukmez O, Ture M, Gorukmez O, Deligonul A, Sahinturk S, Topak A, Gulten T, Kurt E, Yakut T.Springerplus. 2016 Apr 19;5:482. doi: 10.1186/s40064-016-2150-4. eCollection 2016.PMID: 27217997 Free PMC article.
25-Oxytocin system social function impacts in children with attention-deficit/hyperactivity disorder.
Ayaz AB, Karkucak M, Ayaz M, Gokce S, Kayan E, Güler EE, Güngen BD, Kuşcu TD, Ocakoğlu G, Yakut T.Am J Med Genet B Neuropsychiatr Genet. 2015 Oct;168(7):609-16. doi: 10.1002/ajmg.b.32343. Epub 2015 Jul 14.PMID: 26174935
26-The Effects of Bundles on Catheter-Associated Urinary Tract Infections in the Pediatric Intensive Care Unit.
Sönmez Düzkaya D, Bozkurt G, Uysal G, Yakut T.Clin Nurse Spec. 2016 Nov/Dec;30(6):341-346. doi: 10.1097/NUR.0000000000000246.PMID: 27753672
27-The Effect of Oral Care Using an Oral Health Care Guide on Preventing Mucositis in Pediatric Inten-sive Care.
Düzkaya DS, Uysal G, Bozkurt G, Yakut T.J Pediatr Nurs. 2017 Sep-Oct;36:98-102. doi: 10.1016/j.pedn.2017.05.010. Epub 2017 Jun 3.PMID: 28888518
28-Severe hypospadias associated with Robertsonian translocation.
Kilic N, Balkan E, Saglam H, Yakut T, Dogruyol H.Urol Int. 2005;74(4):373-6. doi: 10.1159/000084443.PMID: 15897709
29-Reanalysis of human blastocysts with different molecular genetic screening platforms reveals signifi-cant discordance in ploidy status.
Tortoriello DV, Dayal M, Beyhan Z, Yakut T, Keskintepe L.J Assist Reprod Genet. 2016 Nov;33(11):1467-1471. doi: 10.1007/s10815-016-0766-5. Epub 2016 Jul 16.PMID: 27423662 Free PMC article.
30-The Influence of Polymorphisms of Interleukin-17A and -17F Genes on Susceptibility and Activity of Rheumatoid Arthritis.
Erkol İnal E, Görükmez O, Dündar Ü, Görükmez Ö, Yener M, Özemri Sağ Ş, Yakut T.Genet Test Mol Bi-omarkers. 2015 Aug;19(8):461-4. doi: 10.1089/gtmb.2015.0064. Epub 2015 Jul 8.PMID: 26154773
31-Associations between polymorphisms of IL-17F and IL-17A genes with disease activity and clinical out-come of Ankylosing Spondylitis.
Erkol İnal E, Görükmez O, Eroğlu S, Özemri SŞ, Solak Ö, Görükmez Ö, Yakut T.Acta Reumatol Port. 2016 Jul-Sep;41(3):232-239.PMID: 27155445 Free article. English.
32-The variant translocation of ABL1 gene t(2;9)(q21;q34) in a childhood T-cell acute lymphoblastic leu-kemia.
Karkucak M, Yakut T, Baytan B, Gulten T, Gunes AM.Bratisl Lek Listy. 2012;113(1):19-20. doi: 10.4149/bll_2012_004.PMID: 22380496
33-Association of the ACE I/D gene polymorphisms with JAK2V617F-positive polycythemia vera and essen-tial thrombocythemia.
Gorukmez O, Sag ŞO, Gorukmez Ö, Ture M, Topak A, Sahinturk S, Ozkaya G, Gulten T, Ali R, Yakut T.Genet Test Mol Biomarkers. 2015 Jun;19(6):303-8. doi: 10.1089/gtmb.2014.0334. Epub 2015 May 8.PMID: 25955555
34-Does MBL2 codon 54 polymorphism play a role in the pathogenesis of psoriasis?
Turan H, Karkucak M, Yakut T, Ozsahin M, Gurlevik Z, Yanik ME, Ucgun T, Aliagaoglu C, Yaykasli KO.Int J Dermatol. 2014 Jan;53(1):34-8. doi: 10.1111/j.1365-4632.2012.5657.x. Epub 2012 Nov 1.PMID: 23113841
35-Association between p16(CDKN2A) C540G polymorphism and tumor behavior in prolactinoma: A sin-gle-center study.
Cander S, Karkucak M, Gul OO, Sag SO, Yakut T, Ersoy C, Tuncel E, Erturk E.Biomed Rep. 2014 Jul;2(4):589-595. doi: 10.3892/br.2014.281. Epub 2014 May 19.PMID: 24944814 Free PMC article.
36-Esophageal muscle cell interaction with biopolymers.
Korkmaz M, Yakut T, Narci A, Güvenç BH, Güilten T, Yağmurca M, Yiğit B, Bilir A.Med Sci Monit. 2007 Feb;13(2):BR46-9.PMID: 17261980
37-A dysmorphic newborn with 45,X,der(1)inv(1)(p13;qter)t(Y;1)(pter-->q11;p13),-Y de novo karyotype.
Tatar A, Oztas S, Yakut T, Ors R.Genet Couns. 2005;16(2):173-7.PMID: 16080298
38-Effect of cyclin [corrected] D1 (CCND1) gene polymorphism on tumor formation and behavior in pa-tients with prolactinoma.
Cander S, Ertürk E, Karkucak M, Oz Gül O, Görükmez O, Yakut T, Unal OK, Ersoy C, Tuncel E, Imamoğlu S.Gene. 2012 Nov 1;509(1):158-63. doi: 10.1016/j.gene.2012.07.056. Epub 2012 Aug 8.PMID: 22967707
39-Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder.
Armagan E, Almacıoglu ML, Yakut T, Köse A, Karkucak M, Köksal O, Görükmez O.Genet Mol Res. 2013 Mar 19;12(1):852-8. doi: 10.4238/2013.March.19.1.PMID: 23613193 Free article.
40-Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations.
Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L, Williamson KA, Ture M, Barker H, Rosendahl K, Spranger J, Horn D, Meynert A, Floyd JA, Prescott T, Anderson CA, Rainger JK, Karaca E, Gonzaga-Jauregui C, Jhangiani S, Muzny DM, Seawright A, Soares DC, Kharbanda M, Murday V, Finch A; UK10K; Baylor-Hopkins Center for Mendelian Genomics, Gibbs RA, van Heyningen V, Taylor MS, Yakut T, Knappskog PM, Hurles ME, Ponting CP, Lupski JR, Houge G, FitzPatrick DR.Am J Hum Genet. 2014 Jun 5;94(6):915-23. doi: 10.1016/j.ajhg.2014.05.005.PMID: 24906020 Free PMC article.
41-Qualitative and quantitative evaluation of the BCR-ABL fusion gene in chronic myelogenous leukemia by flourescence in situ hybridization and molecular genetic methods.
Ozemri Sag S, Yakut T, Gorukmez O, Gorukmez O, Ture M, Karkucak M, Gulten T, Ali R.Genet Test Mol Biomarkers. 2015 Oct;19(10):584-8. doi: 10.1089/gtmb.2015.0056. Epub 2015 Aug 26.PMID: 26308792
42-ACE gene I/D polymorphism and risk of sarcoidosis development in Turkish patients.
Yılmaz D, Karkucak M, Coşkun F, Yakut T, Kunt Uzaslan E.Tuberk Toraks. 2012;60(3):201-6. doi: 10.5578/tt.3935.PMID: 23030744 Free article.
43-Evaluation of the JAK2-V617F gene mutation in Turkish patients with essential thrombocythemia and polycythemia vera.
Karkucak M, Yakut T, Ozkocaman V, Ozkalemkas F, Ali R, Bayram M, Gorukmez O, Ocakoglu G.Mol Biol Rep. 2012 Sep;39(9):8663-7. doi: 10.1007/s11033-012-1721-x. Epub 2012 Jun 22.PMID: 22722988
44-A novel mutation in the FRAS1 gene in a patient with Fraser syndrome.
Ozemri Sag S, Gorukmez O, Gorukmez O, Ture M, Sahinturk S, Topak A, Gulten T, Schanze D, Yakut T, Zenker M.Genet Couns. 2015;26(1):21-7.PMID: 26043503
45-A RARE COMBINATION OF 45,X/46,XY MOSAICISM AND Y CHROMOSOME MICRODELETION IN AN INFERTILE MAN WITH AZOOSPERMIA.
Aydemir H, Karkucak M, Cimen HI, Halis F, Kumsar S, Sonbahar AE, Yakut T.Genet Couns. 2016;27(1):95-8.PMID: 27192898 No abstract available.
46-An Unusual Case of LCHAD Deficiency Presenting With a Clinical Picture of Hemophagocytic Lympho-histiocytosis: Secondary HLH or Coincidence?
Erdol S, Ture M, Baytan B, Yakut T, Saglam H.J Pediatr Hematol Oncol. 2016 Nov;38(8):661-662. doi: 10.1097/MPH.0000000000000626.PMID: 27769081
47-Novel TSHR mutations in consanguineous families with congenital nongoitrous hypothyroidism.
Cangul H, Morgan NV, Forman JR, Saglam H, Aycan Z, Yakut T, Gulten T, Tarim O, Bober E, Cesur Y, Kirby GA, Pasha S, Karkucak M, Eren E, Cetinkaya S, Bas V, Demir K, Yuca SA, Meyer E, Kendall M, Hogler W, Barrett TG, Maher ER.Clin Endocrinol (Oxf). 2010 Nov;73(5):671-7. doi: 10.1111/j.1365-2265.2010.03849.x.PMID: 20718767
48-A NOVEL MUTATION IN NPR2 GENE IN A PATIENT WITH ACROMESOMELIC DYSPLASIA, MAROTEAUX TYPE.
Sag SO, Gorukmez O, Topak A, Gorukmez O, Ture M, Sahinturk S, Gulten T, Yakut T.Genet Couns. 2015;26(2):219-25.PMID: 26349192
49-Glutathione s-transferase m1 and t1 gene polymorphisms are not associated with increased risk of gestational diabetes mellitus development.
Orhan O, Atalay MA, Orhan F, Karkucak M, Centinkaya Demir B, Yakut T, Cengiz C.West Indian Med J. 2014 Aug;63(4):300-6. doi: 10.7727/wimj.2013.128. Epub 2014 May 15.PMID: 25429472 Free PMC arti-cle.
50-Investigation of TNF-alpha gene (G308A) and GSTP1 gene (Ilel05Val) polymorphisms in Turkish pa-tients with retinopathy of prematurity.
Türe M, Yildiz M, Karkucak M, Gülten ET, Siğirli D, Özmen AT, Yakut T.Turk J Med Sci. 2015;45(1):164-9. doi: 10.3906/sag-1307-94.PMID: 25790547 Free article.
51-Vitamin a deficiency in patients with common variable immunodeficiency.
Kilic SS, Kezer EY, Ilcol YO, Yakut T, Aydin S, Ulus IH.J Clin Immunol. 2005 May;25(3):275-80. doi: 10.1007/s10875-005-4090-6.PMID: 15981093
52-Comparison of aneuploidy frequencies between in vitro matured and unstimulated cycles oocytes by metaphase comparative genomic hybridization (mCGH).
Yakut T, Karkucak M, Sher G, Keskintepe L.Mol Biol Rep. 2012 May;39(5):6187-91. doi: 10.1007/s11033-011-1436-4. Epub 2011 Dec 30.PMID: 22207182
53-MULTIPLE CONGENITAL ANOMALIES IN A CHILD WITH 47,XY,+der(8;9)(p10;p10): A CASE REPORT.
Gorukmez O, Gorukmez O, Sag OS, Yakut T, Gulten T.Genet Couns. 2015;26(2):163-9.PMID: 26349185
54-Polymorphisms of glutathione-s-transferase M1, T1, and P1 genes in endometrial carcinoma.
Ozerkan K, Atalay MA, Yakut T, Doster Y, Yilmaz E, Karkucak M.Eur J Gynaecol Oncol. 2013;34(1):42-7.PMID: 23589999
55-FISH investigation of 22q11.2 deletion in patients with immunodeficiency and/or cardiac abnormali-ties.
Yakut T, Kilic SS, Cil E, Yapici E, Egeli U.Pediatr Surg Int. 2006 Apr;22(4):380-3. doi: 10.1007/s00383-006-1641-8. Epub 2006 Feb 4.PMID: 16463032
56-GST (GSTM1, GSTT1, and GSTP1) polymorphisms in the genetic susceptibility of Turkish patients to cervical cancer.
Kiran B, Karkucak M, Ozan H, Yakut T, Ozerkan K, Sag S, Ture M.J Gynecol Oncol. 2010 Sep;21(3):169-73. doi: 10.3802/jgo.2010.21.3.169. Epub 2010 Sep 28.PMID: 20922139 Free PMC article.
57-Investigation of Monnose-Binding Lectin gene Polymorphism in Patients with Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syn-drome.
Karkucak M, Bülbül EB, Turan H, Yakut T, Toka S, Sarıcaoğlu H.Balkan Med J. 2012 Sep;29(3):310-3. doi: 10.5152/balkanmedj.2012.018. Epub 2012 Sep 1.PMID: 25207021 Free PMC article.
58-Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease.
Saricaoglu H, Yilmaz M, Karkucak M, Ozturk HZ, Yakut T, Gulten T, Baskan EB, Aydogan K, Dilek K.Genet Mol Res. 2011 Jan 4;10(1):1-6. doi: 10.4238/vol10-1gmr824.PMID: 21218380 Free article.
59-The prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in central serous chorioretinopathy and its association with plasma PAI-1 levels.
Sogutlu Sari E, Yazici A, Eser B, Erol MK, Kilic A, Ermis SS, Koytak A, Akşit H, Yakut T.Cutan Ocul Toxicol. 2014 Dec;33(4):270-4. doi: 10.3109/15569527.2013.854372. Epub 2014 Jan 22.PMID: 24446892
60-Assessment of molecular events in squamous and non-squamous cell lung carcinoma.
Yakut T, Schulten HJ, Demir A, Frank D, Danner B, Egeli U, Gebitekin C, Kahler E, Gunawan B, Urer N, Oztürk H, Füzesi L.Lung Cancer. 2006 Dec;54(3):293-301. doi: 10.1016/j.lungcan.2006.08.011. Epub 2006 Sep 29.PMID: 17011066
61-Frequency of recombinant and nonrecombinant products of pericentric inversion of chromosome 1 in sperm nuclei of carrier: by FISH technique.
Yakut T, Acar H, Egeli U, Kimya Y.Mol Reprod Dev. 2003 Sep;66(1):67-71. doi: 10.1002/mrd.10325.PMID: 12874801
62-Lack of association of genetic polymorphisms of angiotensin-converting enzyme gene I/D and gluta-thione-S-transferase enzyme T1 and M1 with retinopathy of prematures.
Yildiz M, Karkucak M, Yakut T, Gorukmez O, Ozmen A.Genet Mol Res. 2010 Oct 26;9(4):2131-9. doi: 10.4238/vol9-4gmr887.PMID: 21038299 Free article.
63-Effect of Pressure Injury Prevention Guides Used In a Pediatric Intensive Care.
Uysal G, Sönmez Düzkaya D, Yakut T, Bozkurt G.Clin Nurs Res. 2020 May;29(4):249-255. doi: 10.1177/1054773818817696. Epub 2019 Jan 2.PMID: 30599767
64-NOVEL MUTATION OF THE ELECTRON TRANSFERRING FLAVOPROTEIN DEHYDROGENASE (ETFDH) GENE IN THE ISOLATED MYOPATHIC FORM OF COENZYME q10 DEFICIENCY.
Gorukmez O, Gorukmez O, Sag SO, Erdol S, Saglam H, Yakut T.Genet Couns. 2015;26(2):259-62.PMID: 26349199 No abstract available.
Polymorphisms in angiotensin-converting enzyme and glutathione s-transferase genes in Turkish popula-tion and risk for preeclampsia.
Atalay MA, Ozerkan K, Karkucak M, Yakut T, Atik Y, Develioglu OH.Clin Exp Obstet Gynecol. 2012;39(4):466-9.
65-Recurrence of Oligodendroglioma Remote From the Original Site: A Case ReportKocaeli H, Yakut T, Bekar A, Taşkapilioğlu O, Tolunay S.Surg Neurol. 2006 Dec;66(6):627-30; discussion 630-1. doi: 10.1016/j.surneu.2006.02.049. Epub 2006 Oct . 6.PMID: 17145331
66-Toll-like receptor 9 polymorphism in patients with erythema multiforme, Stevens Johnson syndrome and Stevens Johnson syndrome/toxic epidermal necrolysis overlap syndrome.
Turan H, Bulbul Baskan E, Yakut T, Karkucak M, Tunali S, Saricaoglu H.Bratisl Lek Listy. 2011;112(5):260-3.PMID: 21682079
67-Correlation of chromosomal imbalances by comparative genomic hybridization and expression of EGFR, PTEN, p53, and MIB-1 in diffuse gliomas.
Yakut T, Gutenberg A, Bekar A, Egeli U, Gunawan B, Ercan I, Tolunay S, Doygun M, Schulten HJ.Oncol Rep. 2007 May;17(5):1037-43.PMID: 17390041
68-Oocyte karyotyping by comparative genomic hybridization [correction of hybrydization] provides a highly reliable method for selecting "competent" embryos, markedly improving in vitro fertilization out-come: a multiphase study.
69-Sher G, Keskintepe L, Keskintepe M, Ginsburg M, Maassarani G, Yakut T, Baltaci V, Kotze D, Unsal E.Fertil Steril. 2007 May;87(5):1033-40. doi: 10.1016/j.fertnstert.2006.08.108. Epub 2007 Jan 29.PMID: 17258713
70-Pregnancy under treatment of imatinib and successful labor in a patient with chronic myelogenous leukemia (CML). Outcome of discontinuation of imatinib therapy after achieving a molecular remission.
Ali R, Ozkalemkaş F, Ozçelik T, Ozkocaman V, Ozan U, Kimya Y, Köksal N, Gülten T, Yakut T, Tunali A.Leuk Res. 2005 Aug;29(8):971-3. doi: 10.1016/j.leukres.2005.01.009. Epub 2005 Feb 16.PMID: 15978950
71-Cytogenetic results of amniocentesis materials: incidence of abnormal karyotypes in the Turkish col-laborative study.
Karaoguz MY, Bal F, Yakut T, Ercelen NO, Ergun MA, Gokcen AB, Biri AA, Kimya Y, Urman B, Gultomruk M, Egeli U, Menevse S.Genet Couns. 2006;17(2):219-30.PMID: 16970041 Clinical Trial.
72-Extended pedigree with multiple cases of XX sex reversal in the absence of SRY and of a mutation at the SOX9 locus.
Temel SG, Gulten T, Yakut T, Saglam H, Kilic N, Bausch E, Jin WJ, Leipoldt M, Scherer G.Sex Dev. 2007;1(1):24-34. doi: 10.1159/000096236.PMID: 18391513 Free article.
73-Sudden blastic crisis and additional chromosomal abnormalities during chronic myeloid leukemia in the imatinib era.
Ali R, Ozkalemkas F, Ozkocaman V, Yakut T, Nazlioglu HO, Budak F, Pekgoz M, Korkmaz S, Karkucak M, Ozcelik T, Tunali A.Int J Clin Oncol. 2009 Dec;14(6):545-50. doi: 10.1007/s10147-009-0884-5. Epub 2009 Dec 5.PMID: 19967494
74-Prenatal diagnosis of a fetus with pure partial trisomy 1q32-44 due to a familial balanced rearrange-ment.
Kímya Y, Yakut T, Egelí U, Ozerkan K.Prenat Diagn. 2002 Nov;22(11):957-61. doi: 10.1002/pd.403.PMID: 12424755
75-Another small supernumerary marker chromosome derived from chromosome 9 in a Klinefelter pa-tient.
Gulten T, Gorukmez O, Gorukmez O, Karkucak M, Ture M, Yakut T.West Indian Med J. 2012 Dec;61(9):924-7. doi: 10.7727/wimj.2012.027.PMID: 24020236
76-Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
Vatan O, Bilaloglu R, Tunca B, Cecener G, Gebitekin C, Egeli U, Yakut T, Urer N.Tumori. 2007 Sep-Oct;93(5):473-7.PMID: 18038880
77-Impact of concomitant obstructive sleep apnea on pulmonary involvement and main pulmonary artery diameter in adults with scleroderma.
Yakut T, Balcan B, Karakurt S, Direskeneli H, Yalcinkaya Y, Peker Y.Sleep Breath. 2020 Apr 13. doi: 10.1007/s11325-020-02059-4. Online ahead of print.PMID: 32285251
78-Determination of allelic deletion of multiple endocrine neoplasm type 1 (MEN1) gene in acute mye-loid leukemia (AML) by application of FISH-TSA technique.
Acar H, Kaynak M, Yakut T, Uçar F, Egeli U.Teratog Carcinog Mutagen. 2002;22(5):369-75. doi: 10.1002/tcm.10033.PMID: 12210500
79-Pantothenate kinase-associated neurodegeneration (PKAN): molecular confirmation of a Turkish pa-tient with a rare frameshift mutation in the coding region of the PANK2 gene.
Cangül H, Ozdemir O, Yakut T, Okan M, Morgan NV, Baytan B, Kurian MA, Spiegel R, Maher ER.Turk J Pediatr. 2009 Mar-Apr;51(2):161-5.PMID: 19480328
80-Lack of association of ACE gene I/D polymorphism with obstructive sleep apnea syndrome in Turkish patients.
Yakut T, Karkucak M, Ursavas A, Gulten T, Burgazlioglu B, Gorukmez O, Karadag M.Genet Mol Res. 2010 Apr 20;9(2):734-8. doi: 10.4238/vol9-2gmr755.PMID: 20449805 Free article.
81-AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia.
Gulten T, Yakut T, Karkucak M, Baytan B, Guneş AM.J Clin Lab Anal. 2009;23(6):368-71. doi: 10.1002/jcla.20343.PMID: 19927343 Free PMC article.
1-Evaluation of relationship between chromosome 22 and p53 gene alterations and the subtype of men-ingiomas by the interphase-FISH technique.
Yakut T, Bekar A, Doygun M, Acar H, Egeli U, Ogul E.Teratog Carcinog Mutagen. 2002;22(3):217-25. doi: 10.1002/tcm.10013.PMID: 11948632
2-Comparison of genetic changes between interphase and metaphase nuclei in monitoring CML and APL treatment using DC-FISH technique.
Yakut T, Ali R, Egeli U, Ozkalemkas F, Ercan I, Ozçelik T, Ozkocaman V, Yigit B, Tunali A.Cancer Biol Ther. 2004 Sep;3(9):858-63. doi: 10.4161/cbt.3.9.1039. Epub 2004 Sep 18.PMID: 15254420
3-Investigation of c-myc and p53 gene alterations in the tumor and surgical borderline tissues of NSCLC and effects on clinicopathologic behavior: by the FISH technique.
Yakut T, Egeli U, Gebitekin C.Lung. 2003;181(5):245-58. doi: 10.1007/s00408-003-1026-x.PMID: 14705768
Cite
4-Toll-like receptor-9 gene polymorphism in common variable immunodeficiency.
Tanir S, Karkucak M, Yakut T, Kilic SS.J Investig Allergol Clin Immunol. 2010;20(3):267-8.PMID: 20635795 Free article. No abstract available.
5-Genes that Affect Brain Structure and Function Identified by Rare Variant Analyses of Mendelian Neuro-logic Disease.
Karaca E, Harel T, Pehlivan D, Jhangiani SN, Gambin T, Coban Akdemir Z, Gonzaga-Jauregui C, Erdin S, Bayram Y, Campbell IM, Hunter JV, Atik MM, Van Esch H, Yuan B, Wiszniewski W, Isikay S, Yesil G, Yuregir OO, Tug Bozdogan S, Aslan H, Aydin H, Tos T, Aksoy A, De Vivo DC, Jain P, Geckinli BB, Sezer O, Gul D, Durmaz B, Cogulu O, Ozkinay F, Topcu V, Candan S, Cebi AH, Ikbal M, Yilmaz Gulec E, Gezdirici A, Koparir E, Ekici F, Coskun S, Cicek S, Karaer K, Koparir A, Duz MB, Kirat E, Fenercioglu E, Ulucan H, Seven M, Guran T, Elcioglu N, Yildirim MS, Aktas D, Alikaşifoğlu M, Ture M, Yakut T, Overton JD, Yuksel A, Ozen M, Muzny DM, Adams DR, Boerwinkle E, Chung WK, Gibbs RA, Lupski JR.Neuron. 2015 Nov 4;88(3):499-513. doi: 10.1016/j.neuron.2015.09.048.PMID: 26539891 Free PMC article.
6-A fertile patient with 45X/47XXX mosaicism.
Sahinturk S, Ozemri Sag S, Ture M, Gorukmez O, Topak A, Yakut T, Gulten T.Genet Couns. 2015;26(1):29-34.PMID: 26043504
Cite
7-De novo partial trisomy distal 4q: a case report.
Gorukmez O, Sag SO, Gorukmez O, Ture M, Gulten T, Yakut T.Genet Couns. 2014;25(4):423-8.PMID: 25804022
8-MMP2 gene-735 C/T and MMP9 gene -1562 C/T polymorphisms in JAK2V617F positive myeloprolifera-tive disorders.
Sag SO, Gorukmez O, Ture M, Gorukmez O, Topak A, Sahinturk S, Ocakoglu G, Gulten T, Ali R, Yakut T.Asian Pac J Cancer Prev. 2015;16(2):443-9. doi: 10.7314/apjcp.2015.16.2.443.PMID: 25684469 Free ar-ticle.
9-Dyskeratosis Congenita: A Case Report.
Ozemri Sag S, Topak A, Gorukmez O, Gorukmez O, Ture M, Carrillo J, Sahinturk S, Gulten T, Perona R, Yakut T.Genet Couns. 2016;27(2):263-7.PMID: 29485835 No abstract available.
10-Meiotic segregation analysis of reciprocal translocations both in sperms and blastomeres.
Yakut T, Ercelen N, Acar H, Kimya Y, Egeli U.Am J Med Genet A. 2006 May 15;140(10):1074-82. doi: 10.1002/ajmg.a.31215.PMID: 16596678
11-Association and Prognostic Significance of the Functional -1562C/T Polymorphism in the Promoter Region of MMP-9 in Turkish Patients with Gastric Cancer.
Avcı N, Ture M, Deligonul A, Cubukcu E, Olmez OF, Sahinturk S, Topak A, Kurt E, Evrensel T, Şahin AB, Yakut T.Pathol Oncol Res. 2015 Sep;21(4):1243-7. doi: 10.1007/s12253-015-9950-7. Epub 2015 Jul 9.PMID: 26156886
12-GSTT1 and GSTM1 gene polymorphisims in sarcoidosis.
Coskun F, Karkucak M, Yilmaz D, Yakut T, Uzaslan E.Sarcoidosis Vasc Diffuse Lung Dis. 2016 Oct 7;33(3):253-257.PMID: 27758991
13-Delayed Puberty and Gonadal Failure in Patients with HAX1 Mutation.
Cekic S, Saglam H, Gorukmez O, Yakut T, Tarim O, Kilic SS.J Clin Immunol. 2017 Aug;37(6):524-528. doi: 10.1007/s10875-017-0412-8. Epub 2017 Jul 5.PMID: 28681255
14-Investigation of MEFV gene polymorphisms (G138G and A165A) in adult patients with familial Medi-terranean fever.
Öksuz MF, Karkucak M, Görukmez O, Ocakoğlu G, Yıldız A, Ture M, Yakut T, Dilek K.Rev Bras Reumatol Engl Ed. 2017 Nov-Dec;57(6):501-506. doi: 10.1016/j.rbre.2016.02.004. Epub 2016 Mar 10.PMID: 29173686 Free article. English, Portuguese.
15-TURNER SYNDROME WITH 45,X/46,X,I(Xq)/47,X,I(Xq),I(Xq) KARYOTYPE.
Gorukmez O, Sag SO, Gulten T, Gorukmez, Ture M, Yakut T.Genet Couns. 2015;26(2):267-9.PMID: 26349201 No abstract available.
16-Associations analysis of GSTM1, T1 and P1 Ile105Val polymorphisms with carpal tunnel syndrome.
Eroğlu P, Erkol İnal E, Sağ ŞÖ, Görükmez Ö, Topak A, Yakut T.Clin Rheumatol. 2016 May;35(5):1245-51. doi: 10.1007/s10067-014-2855-0. Epub 2015 Jan 9.PMID: 25566970
17-Association of GSTM1, GSTT1, GSTP1-ILE105VAL and ACE I/D polymorphisms with ankylosing spondyli-tis.
İnal EE, Görükmez O, Eroğlu S, Görükmez Ö, Solak Ö, Topak A, Yakut T.Rheumatol Int. 2016 Jan;36(1):17-23. doi: 10.1007/s00296-015-3317-y. Epub 2015 Jul 18.PMID: 26186891
18-Evaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosis.
Ceylan E, Karkucak M, Coban H, Karadag M, Yakut T.J Infect Public Health. 2017 Nov-Dec;10(6):774-777. doi: 10.1016/j.jiph.2016.11.003. Epub 2017 Feb 8.PMID: 28189510 Free article.
19-Association between the catechol-o-methyltransferase val158met polymorphism with susceptibility and severity of carpal tunnel syndrome.
Erkol İnal E, Eroğlu P, Görükmez O, Özemri Sağ Ş, Yakut T.Balkan J Med Genet. 2016 Jul 9;18(2):43-48. doi: 10.1515/bjmg-2015-0085. eCollection 2015 Dec 1.PMID: 27785396 Free PMC article.
20-Distribution of KRAS and BRAF Mutations in Metastatic Colorectal Cancers in Turkish Patients.
Gorukmez O, Yakut T, Gorukmez O, Sag SO, Karkucak M, Kanat O.Asian Pac J Cancer Prev. 2016;17(3):1175-9. doi: 10.7314/apjcp.2016.17.3.1175.PMID: 27039744 Free article.
21-CLINICAL EFFECT OF A MUTATION (p.Glu322Asp, c.966 G>T) IN PANK2 GENE IN A FAMILY WITH ATYP-ICAL PANTOTHENATE KINASE-ASSOCIATED NEURODEGENERATION.
Ayas ZO, Karkucak M, Ocal RO, Yakut T.Genet Couns. 2016;27(4):489-494.PMID: 30226968
22-Glutathione S-transferase T1, M1 and P1 Genetic Polymorphisms and Susceptibility to Colorectal Can-cer in Turkey.
Gorukmez O, Yakut T, Gorukmez O, Sag SO, Topak A, Sahinturk S, Kanat O.Asian Pac J Cancer Prev. 2016;17(8):3855-9.PMID: 27644629 Free article.
23-Glutathione S-Transferase M1 and T1 Gene Polymorphisms in Patients with Chronic Plaque-Type Pso-riasis: A Case-Control Study.
Solak B, Karkucak M, Turan H, Ocakoğlu G, Özemri Sağ Ş, Uslu E, Yakut T, Erdem T.Med Princ Pract. 2016;25(2):155-8. doi: 10.1159/000442165. Epub 2015 Nov 4.PMID: 26535568 Free PMC article.
24Spectrum of EGFR gene mutations and ALK rearrangements in lung cancer patients in Turkey.
Sag SO, Gorukmez O, Ture M, Gorukmez O, Deligonul A, Sahinturk S, Topak A, Gulten T, Kurt E, Yakut T.Springerplus. 2016 Apr 19;5:482. doi: 10.1186/s40064-016-2150-4. eCollection 2016.PMID: 27217997 Free PMC article.
25-Oxytocin system social function impacts in children with attention-deficit/hyperactivity disorder.
Ayaz AB, Karkucak M, Ayaz M, Gokce S, Kayan E, Güler EE, Güngen BD, Kuşcu TD, Ocakoğlu G, Yakut T.Am J Med Genet B Neuropsychiatr Genet. 2015 Oct;168(7):609-16. doi: 10.1002/ajmg.b.32343. Epub 2015 Jul 14.PMID: 26174935
26-The Effects of Bundles on Catheter-Associated Urinary Tract Infections in the Pediatric Intensive Care Unit.
Sönmez Düzkaya D, Bozkurt G, Uysal G, Yakut T.Clin Nurse Spec. 2016 Nov/Dec;30(6):341-346. doi: 10.1097/NUR.0000000000000246.PMID: 27753672
27-The Effect of Oral Care Using an Oral Health Care Guide on Preventing Mucositis in Pediatric Inten-sive Care.
Düzkaya DS, Uysal G, Bozkurt G, Yakut T.J Pediatr Nurs. 2017 Sep-Oct;36:98-102. doi: 10.1016/j.pedn.2017.05.010. Epub 2017 Jun 3.PMID: 28888518
28-Severe hypospadias associated with Robertsonian translocation.
Kilic N, Balkan E, Saglam H, Yakut T, Dogruyol H.Urol Int. 2005;74(4):373-6. doi: 10.1159/000084443.PMID: 15897709
29-Reanalysis of human blastocysts with different molecular genetic screening platforms reveals signifi-cant discordance in ploidy status.
Tortoriello DV, Dayal M, Beyhan Z, Yakut T, Keskintepe L.J Assist Reprod Genet. 2016 Nov;33(11):1467-1471. doi: 10.1007/s10815-016-0766-5. Epub 2016 Jul 16.PMID: 27423662 Free PMC article.
30-The Influence of Polymorphisms of Interleukin-17A and -17F Genes on Susceptibility and Activity of Rheumatoid Arthritis.
Erkol İnal E, Görükmez O, Dündar Ü, Görükmez Ö, Yener M, Özemri Sağ Ş, Yakut T.Genet Test Mol Bi-omarkers. 2015 Aug;19(8):461-4. doi: 10.1089/gtmb.2015.0064. Epub 2015 Jul 8.PMID: 26154773
31-Associations between polymorphisms of IL-17F and IL-17A genes with disease activity and clinical out-come of Ankylosing Spondylitis.
Erkol İnal E, Görükmez O, Eroğlu S, Özemri SŞ, Solak Ö, Görükmez Ö, Yakut T.Acta Reumatol Port. 2016 Jul-Sep;41(3):232-239.PMID: 27155445 Free article. English.
32-The variant translocation of ABL1 gene t(2;9)(q21;q34) in a childhood T-cell acute lymphoblastic leu-kemia.
Karkucak M, Yakut T, Baytan B, Gulten T, Gunes AM.Bratisl Lek Listy. 2012;113(1):19-20. doi: 10.4149/bll_2012_004.PMID: 22380496
33-Association of the ACE I/D gene polymorphisms with JAK2V617F-positive polycythemia vera and essen-tial thrombocythemia.
Gorukmez O, Sag ŞO, Gorukmez Ö, Ture M, Topak A, Sahinturk S, Ozkaya G, Gulten T, Ali R, Yakut T.Genet Test Mol Biomarkers. 2015 Jun;19(6):303-8. doi: 10.1089/gtmb.2014.0334. Epub 2015 May 8.PMID: 25955555
34-Does MBL2 codon 54 polymorphism play a role in the pathogenesis of psoriasis?
Turan H, Karkucak M, Yakut T, Ozsahin M, Gurlevik Z, Yanik ME, Ucgun T, Aliagaoglu C, Yaykasli KO.Int J Dermatol. 2014 Jan;53(1):34-8. doi: 10.1111/j.1365-4632.2012.5657.x. Epub 2012 Nov 1.PMID: 23113841
35-Association between p16(CDKN2A) C540G polymorphism and tumor behavior in prolactinoma: A sin-gle-center study.
Cander S, Karkucak M, Gul OO, Sag SO, Yakut T, Ersoy C, Tuncel E, Erturk E.Biomed Rep. 2014 Jul;2(4):589-595. doi: 10.3892/br.2014.281. Epub 2014 May 19.PMID: 24944814 Free PMC article.
36-Esophageal muscle cell interaction with biopolymers.
Korkmaz M, Yakut T, Narci A, Güvenç BH, Güilten T, Yağmurca M, Yiğit B, Bilir A.Med Sci Monit. 2007 Feb;13(2):BR46-9.PMID: 17261980
37-A dysmorphic newborn with 45,X,der(1)inv(1)(p13;qter)t(Y;1)(pter-->q11;p13),-Y de novo karyotype.
Tatar A, Oztas S, Yakut T, Ors R.Genet Couns. 2005;16(2):173-7.PMID: 16080298
38-Effect of cyclin [corrected] D1 (CCND1) gene polymorphism on tumor formation and behavior in pa-tients with prolactinoma.
Cander S, Ertürk E, Karkucak M, Oz Gül O, Görükmez O, Yakut T, Unal OK, Ersoy C, Tuncel E, Imamoğlu S.Gene. 2012 Nov 1;509(1):158-63. doi: 10.1016/j.gene.2012.07.056. Epub 2012 Aug 8.PMID: 22967707
39-Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder.
Armagan E, Almacıoglu ML, Yakut T, Köse A, Karkucak M, Köksal O, Görükmez O.Genet Mol Res. 2013 Mar 19;12(1):852-8. doi: 10.4238/2013.March.19.1.PMID: 23613193 Free article.
40-Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations.
Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L, Williamson KA, Ture M, Barker H, Rosendahl K, Spranger J, Horn D, Meynert A, Floyd JA, Prescott T, Anderson CA, Rainger JK, Karaca E, Gonzaga-Jauregui C, Jhangiani S, Muzny DM, Seawright A, Soares DC, Kharbanda M, Murday V, Finch A; UK10K; Baylor-Hopkins Center for Mendelian Genomics, Gibbs RA, van Heyningen V, Taylor MS, Yakut T, Knappskog PM, Hurles ME, Ponting CP, Lupski JR, Houge G, FitzPatrick DR.Am J Hum Genet. 2014 Jun 5;94(6):915-23. doi: 10.1016/j.ajhg.2014.05.005.PMID: 24906020 Free PMC article.
41-Qualitative and quantitative evaluation of the BCR-ABL fusion gene in chronic myelogenous leukemia by flourescence in situ hybridization and molecular genetic methods.
Ozemri Sag S, Yakut T, Gorukmez O, Gorukmez O, Ture M, Karkucak M, Gulten T, Ali R.Genet Test Mol Biomarkers. 2015 Oct;19(10):584-8. doi: 10.1089/gtmb.2015.0056. Epub 2015 Aug 26.PMID: 26308792
42-ACE gene I/D polymorphism and risk of sarcoidosis development in Turkish patients.
Yılmaz D, Karkucak M, Coşkun F, Yakut T, Kunt Uzaslan E.Tuberk Toraks. 2012;60(3):201-6. doi: 10.5578/tt.3935.PMID: 23030744 Free article.
43-Evaluation of the JAK2-V617F gene mutation in Turkish patients with essential thrombocythemia and polycythemia vera.
Karkucak M, Yakut T, Ozkocaman V, Ozkalemkas F, Ali R, Bayram M, Gorukmez O, Ocakoglu G.Mol Biol Rep. 2012 Sep;39(9):8663-7. doi: 10.1007/s11033-012-1721-x. Epub 2012 Jun 22.PMID: 22722988
44-A novel mutation in the FRAS1 gene in a patient with Fraser syndrome.
Ozemri Sag S, Gorukmez O, Gorukmez O, Ture M, Sahinturk S, Topak A, Gulten T, Schanze D, Yakut T, Zenker M.Genet Couns. 2015;26(1):21-7.PMID: 26043503
45-A RARE COMBINATION OF 45,X/46,XY MOSAICISM AND Y CHROMOSOME MICRODELETION IN AN INFERTILE MAN WITH AZOOSPERMIA.
Aydemir H, Karkucak M, Cimen HI, Halis F, Kumsar S, Sonbahar AE, Yakut T.Genet Couns. 2016;27(1):95-8.PMID: 27192898 No abstract available.
46-An Unusual Case of LCHAD Deficiency Presenting With a Clinical Picture of Hemophagocytic Lympho-histiocytosis: Secondary HLH or Coincidence?
Erdol S, Ture M, Baytan B, Yakut T, Saglam H.J Pediatr Hematol Oncol. 2016 Nov;38(8):661-662. doi: 10.1097/MPH.0000000000000626.PMID: 27769081
47-Novel TSHR mutations in consanguineous families with congenital nongoitrous hypothyroidism.
Cangul H, Morgan NV, Forman JR, Saglam H, Aycan Z, Yakut T, Gulten T, Tarim O, Bober E, Cesur Y, Kirby GA, Pasha S, Karkucak M, Eren E, Cetinkaya S, Bas V, Demir K, Yuca SA, Meyer E, Kendall M, Hogler W, Barrett TG, Maher ER.Clin Endocrinol (Oxf). 2010 Nov;73(5):671-7. doi: 10.1111/j.1365-2265.2010.03849.x.PMID: 20718767
48-A NOVEL MUTATION IN NPR2 GENE IN A PATIENT WITH ACROMESOMELIC DYSPLASIA, MAROTEAUX TYPE.
Sag SO, Gorukmez O, Topak A, Gorukmez O, Ture M, Sahinturk S, Gulten T, Yakut T.Genet Couns. 2015;26(2):219-25.PMID: 26349192
49-Glutathione s-transferase m1 and t1 gene polymorphisms are not associated with increased risk of gestational diabetes mellitus development.
Orhan O, Atalay MA, Orhan F, Karkucak M, Centinkaya Demir B, Yakut T, Cengiz C.West Indian Med J. 2014 Aug;63(4):300-6. doi: 10.7727/wimj.2013.128. Epub 2014 May 15.PMID: 25429472 Free PMC arti-cle.
50-Investigation of TNF-alpha gene (G308A) and GSTP1 gene (Ilel05Val) polymorphisms in Turkish pa-tients with retinopathy of prematurity.
Türe M, Yildiz M, Karkucak M, Gülten ET, Siğirli D, Özmen AT, Yakut T.Turk J Med Sci. 2015;45(1):164-9. doi: 10.3906/sag-1307-94.PMID: 25790547 Free article.
51-Vitamin a deficiency in patients with common variable immunodeficiency.
Kilic SS, Kezer EY, Ilcol YO, Yakut T, Aydin S, Ulus IH.J Clin Immunol. 2005 May;25(3):275-80. doi: 10.1007/s10875-005-4090-6.PMID: 15981093
52-Comparison of aneuploidy frequencies between in vitro matured and unstimulated cycles oocytes by metaphase comparative genomic hybridization (mCGH).
Yakut T, Karkucak M, Sher G, Keskintepe L.Mol Biol Rep. 2012 May;39(5):6187-91. doi: 10.1007/s11033-011-1436-4. Epub 2011 Dec 30.PMID: 22207182
53-MULTIPLE CONGENITAL ANOMALIES IN A CHILD WITH 47,XY,+der(8;9)(p10;p10): A CASE REPORT.
Gorukmez O, Gorukmez O, Sag OS, Yakut T, Gulten T.Genet Couns. 2015;26(2):163-9.PMID: 26349185
54-Polymorphisms of glutathione-s-transferase M1, T1, and P1 genes in endometrial carcinoma.
Ozerkan K, Atalay MA, Yakut T, Doster Y, Yilmaz E, Karkucak M.Eur J Gynaecol Oncol. 2013;34(1):42-7.PMID: 23589999
55-FISH investigation of 22q11.2 deletion in patients with immunodeficiency and/or cardiac abnormali-ties.
Yakut T, Kilic SS, Cil E, Yapici E, Egeli U.Pediatr Surg Int. 2006 Apr;22(4):380-3. doi: 10.1007/s00383-006-1641-8. Epub 2006 Feb 4.PMID: 16463032
56-GST (GSTM1, GSTT1, and GSTP1) polymorphisms in the genetic susceptibility of Turkish patients to cervical cancer.
Kiran B, Karkucak M, Ozan H, Yakut T, Ozerkan K, Sag S, Ture M.J Gynecol Oncol. 2010 Sep;21(3):169-73. doi: 10.3802/jgo.2010.21.3.169. Epub 2010 Sep 28.PMID: 20922139 Free PMC article.
57-Investigation of Monnose-Binding Lectin gene Polymorphism in Patients with Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syn-drome.
Karkucak M, Bülbül EB, Turan H, Yakut T, Toka S, Sarıcaoğlu H.Balkan Med J. 2012 Sep;29(3):310-3. doi: 10.5152/balkanmedj.2012.018. Epub 2012 Sep 1.PMID: 25207021 Free PMC article.
58-Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease.
Saricaoglu H, Yilmaz M, Karkucak M, Ozturk HZ, Yakut T, Gulten T, Baskan EB, Aydogan K, Dilek K.Genet Mol Res. 2011 Jan 4;10(1):1-6. doi: 10.4238/vol10-1gmr824.PMID: 21218380 Free article.
59-The prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in central serous chorioretinopathy and its association with plasma PAI-1 levels.
Sogutlu Sari E, Yazici A, Eser B, Erol MK, Kilic A, Ermis SS, Koytak A, Akşit H, Yakut T.Cutan Ocul Toxicol. 2014 Dec;33(4):270-4. doi: 10.3109/15569527.2013.854372. Epub 2014 Jan 22.PMID: 24446892
60-Assessment of molecular events in squamous and non-squamous cell lung carcinoma.
Yakut T, Schulten HJ, Demir A, Frank D, Danner B, Egeli U, Gebitekin C, Kahler E, Gunawan B, Urer N, Oztürk H, Füzesi L.Lung Cancer. 2006 Dec;54(3):293-301. doi: 10.1016/j.lungcan.2006.08.011. Epub 2006 Sep 29.PMID: 17011066
61-Frequency of recombinant and nonrecombinant products of pericentric inversion of chromosome 1 in sperm nuclei of carrier: by FISH technique.
Yakut T, Acar H, Egeli U, Kimya Y.Mol Reprod Dev. 2003 Sep;66(1):67-71. doi: 10.1002/mrd.10325.PMID: 12874801
62-Lack of association of genetic polymorphisms of angiotensin-converting enzyme gene I/D and gluta-thione-S-transferase enzyme T1 and M1 with retinopathy of prematures.
Yildiz M, Karkucak M, Yakut T, Gorukmez O, Ozmen A.Genet Mol Res. 2010 Oct 26;9(4):2131-9. doi: 10.4238/vol9-4gmr887.PMID: 21038299 Free article.
63-Effect of Pressure Injury Prevention Guides Used In a Pediatric Intensive Care.
Uysal G, Sönmez Düzkaya D, Yakut T, Bozkurt G.Clin Nurs Res. 2020 May;29(4):249-255. doi: 10.1177/1054773818817696. Epub 2019 Jan 2.PMID: 30599767
64-NOVEL MUTATION OF THE ELECTRON TRANSFERRING FLAVOPROTEIN DEHYDROGENASE (ETFDH) GENE IN THE ISOLATED MYOPATHIC FORM OF COENZYME q10 DEFICIENCY.
Gorukmez O, Gorukmez O, Sag SO, Erdol S, Saglam H, Yakut T.Genet Couns. 2015;26(2):259-62.PMID: 26349199 No abstract available.
Polymorphisms in angiotensin-converting enzyme and glutathione s-transferase genes in Turkish popula-tion and risk for preeclampsia.
Atalay MA, Ozerkan K, Karkucak M, Yakut T, Atik Y, Develioglu OH.Clin Exp Obstet Gynecol. 2012;39(4):466-9.
65-Recurrence of Oligodendroglioma Remote From the Original Site: A Case ReportKocaeli H, Yakut T, Bekar A, Taşkapilioğlu O, Tolunay S.Surg Neurol. 2006 Dec;66(6):627-30; discussion 630-1. doi: 10.1016/j.surneu.2006.02.049. Epub 2006 Oct . 6.PMID: 17145331
66-Toll-like receptor 9 polymorphism in patients with erythema multiforme, Stevens Johnson syndrome and Stevens Johnson syndrome/toxic epidermal necrolysis overlap syndrome.
Turan H, Bulbul Baskan E, Yakut T, Karkucak M, Tunali S, Saricaoglu H.Bratisl Lek Listy. 2011;112(5):260-3.PMID: 21682079
67-Correlation of chromosomal imbalances by comparative genomic hybridization and expression of EGFR, PTEN, p53, and MIB-1 in diffuse gliomas.
Yakut T, Gutenberg A, Bekar A, Egeli U, Gunawan B, Ercan I, Tolunay S, Doygun M, Schulten HJ.Oncol Rep. 2007 May;17(5):1037-43.PMID: 17390041
68-Oocyte karyotyping by comparative genomic hybridization [correction of hybrydization] provides a highly reliable method for selecting "competent" embryos, markedly improving in vitro fertilization out-come: a multiphase study.
69-Sher G, Keskintepe L, Keskintepe M, Ginsburg M, Maassarani G, Yakut T, Baltaci V, Kotze D, Unsal E.Fertil Steril. 2007 May;87(5):1033-40. doi: 10.1016/j.fertnstert.2006.08.108. Epub 2007 Jan 29.PMID: 17258713
70-Pregnancy under treatment of imatinib and successful labor in a patient with chronic myelogenous leukemia (CML). Outcome of discontinuation of imatinib therapy after achieving a molecular remission.
Ali R, Ozkalemkaş F, Ozçelik T, Ozkocaman V, Ozan U, Kimya Y, Köksal N, Gülten T, Yakut T, Tunali A.Leuk Res. 2005 Aug;29(8):971-3. doi: 10.1016/j.leukres.2005.01.009. Epub 2005 Feb 16.PMID: 15978950
71-Cytogenetic results of amniocentesis materials: incidence of abnormal karyotypes in the Turkish col-laborative study.
Karaoguz MY, Bal F, Yakut T, Ercelen NO, Ergun MA, Gokcen AB, Biri AA, Kimya Y, Urman B, Gultomruk M, Egeli U, Menevse S.Genet Couns. 2006;17(2):219-30.PMID: 16970041 Clinical Trial.
72-Extended pedigree with multiple cases of XX sex reversal in the absence of SRY and of a mutation at the SOX9 locus.
Temel SG, Gulten T, Yakut T, Saglam H, Kilic N, Bausch E, Jin WJ, Leipoldt M, Scherer G.Sex Dev. 2007;1(1):24-34. doi: 10.1159/000096236.PMID: 18391513 Free article.
73-Sudden blastic crisis and additional chromosomal abnormalities during chronic myeloid leukemia in the imatinib era.
Ali R, Ozkalemkas F, Ozkocaman V, Yakut T, Nazlioglu HO, Budak F, Pekgoz M, Korkmaz S, Karkucak M, Ozcelik T, Tunali A.Int J Clin Oncol. 2009 Dec;14(6):545-50. doi: 10.1007/s10147-009-0884-5. Epub 2009 Dec 5.PMID: 19967494
74-Prenatal diagnosis of a fetus with pure partial trisomy 1q32-44 due to a familial balanced rearrange-ment.
Kímya Y, Yakut T, Egelí U, Ozerkan K.Prenat Diagn. 2002 Nov;22(11):957-61. doi: 10.1002/pd.403.PMID: 12424755
75-Another small supernumerary marker chromosome derived from chromosome 9 in a Klinefelter pa-tient.
Gulten T, Gorukmez O, Gorukmez O, Karkucak M, Ture M, Yakut T.West Indian Med J. 2012 Dec;61(9):924-7. doi: 10.7727/wimj.2012.027.PMID: 24020236
76-Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
Vatan O, Bilaloglu R, Tunca B, Cecener G, Gebitekin C, Egeli U, Yakut T, Urer N.Tumori. 2007 Sep-Oct;93(5):473-7.PMID: 18038880
77-Impact of concomitant obstructive sleep apnea on pulmonary involvement and main pulmonary artery diameter in adults with scleroderma.
Yakut T, Balcan B, Karakurt S, Direskeneli H, Yalcinkaya Y, Peker Y.Sleep Breath. 2020 Apr 13. doi: 10.1007/s11325-020-02059-4. Online ahead of print.PMID: 32285251
78-Determination of allelic deletion of multiple endocrine neoplasm type 1 (MEN1) gene in acute mye-loid leukemia (AML) by application of FISH-TSA technique.
Acar H, Kaynak M, Yakut T, Uçar F, Egeli U.Teratog Carcinog Mutagen. 2002;22(5):369-75. doi: 10.1002/tcm.10033.PMID: 12210500
79-Pantothenate kinase-associated neurodegeneration (PKAN): molecular confirmation of a Turkish pa-tient with a rare frameshift mutation in the coding region of the PANK2 gene.
Cangül H, Ozdemir O, Yakut T, Okan M, Morgan NV, Baytan B, Kurian MA, Spiegel R, Maher ER.Turk J Pediatr. 2009 Mar-Apr;51(2):161-5.PMID: 19480328
80-Lack of association of ACE gene I/D polymorphism with obstructive sleep apnea syndrome in Turkish patients.
Yakut T, Karkucak M, Ursavas A, Gulten T, Burgazlioglu B, Gorukmez O, Karadag M.Genet Mol Res. 2010 Apr 20;9(2):734-8. doi: 10.4238/vol9-2gmr755.PMID: 20449805 Free article.
81-AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia.
Gulten T, Yakut T, Karkucak M, Baytan B, Guneş AM.J Clin Lab Anal. 2009;23(6):368-71. doi: 10.1002/jcla.20343.PMID: 19927343 Free PMC article.
• Medical Genetics Association
• Turkish Medical Association
• European Cytogenetics Association
• Turkish Medical Association
• European Cytogenetics Association
Awards:
1- 39th Turkish Pediatrics Congress 1st Poster Award. Kılıç Ş, Akpınar R, Yakut T, Egeli Ü. Screening of Di George Syndrome with FISH method in patients with midline defect and congenital heart dis-ease, June 17-22, 2003, Cappadocia.
2- Eurepean Conference of Human Genetics - June 12-15, 2004, Poster (Award 300 Euro + Registra-tion + Fellowship). Munich, Germany. Tahsin YAKUT, Nesrin ERCELEN, Hasan ACAR, Yalcin KIMYA, Ahmet Yilmaz, Barboros YIGIT, Unal EGELI. Analysis of meiotic segregation products of different kind of balanced chromosomal rearrangements in sperm nuclei of carriers; FISH analysis with dif-ferent probe combinations. Vol 12, Suppl. 1, 12-15 May 2004, Munich.
3- M Korkmaz, T Yakut, BH Güvenç, A Bilir. Intraabdominal anastomosis of esophagus segment creat-ed with tissue culture. XXIII. National Pediatric Surgery Congress, 21-24 September, 2005, Gazian-tep.
4- Year 2006 Award for third place according to first name publication, Uludag University, Scientific Research Awards
5- Uludag University, Annual Publishing and Artistic Performance Awards, Annual Publishing Perfor-mance Achievement Award, 2013
1- 39th Turkish Pediatrics Congress 1st Poster Award. Kılıç Ş, Akpınar R, Yakut T, Egeli Ü. Screening of Di George Syndrome with FISH method in patients with midline defect and congenital heart dis-ease, June 17-22, 2003, Cappadocia.
2- Eurepean Conference of Human Genetics - June 12-15, 2004, Poster (Award 300 Euro + Registra-tion + Fellowship). Munich, Germany. Tahsin YAKUT, Nesrin ERCELEN, Hasan ACAR, Yalcin KIMYA, Ahmet Yilmaz, Barboros YIGIT, Unal EGELI. Analysis of meiotic segregation products of different kind of balanced chromosomal rearrangements in sperm nuclei of carriers; FISH analysis with dif-ferent probe combinations. Vol 12, Suppl. 1, 12-15 May 2004, Munich.
3- M Korkmaz, T Yakut, BH Güvenç, A Bilir. Intraabdominal anastomosis of esophagus segment creat-ed with tissue culture. XXIII. National Pediatric Surgery Congress, 21-24 September, 2005, Gazian-tep.
4- Year 2006 Award for third place according to first name publication, Uludag University, Scientific Research Awards
5- Uludag University, Annual Publishing and Artistic Performance Awards, Annual Publishing Perfor-mance Achievement Award, 2013