Recurrent Pregnancy Losses

Miscarriage before 20th gestational week is considered as pregnancy loss. Genetic factors (numerical or structural anomaly of chromosomes of embryo) cause 50-75% of pregnancy losses. one percent of women in reproductive period experience pregnancy loss of 3 or more. This is called recurrent pregnancy losses.



 

When should pregnancy losses be investigated?

If the heart rate is heard in the embryo and especially the loss occurs in the second trimester,
If normal karyotype analysis has been reported in the genetic examination of previous pregnancy loss,
If the maternal age is over 35,
If the mother has infertility,
If there is anomaly in the karyotype (genetic) analysis of the mother and / or father

if there is a loss of 3 or more it is defined recurrent pregnancy loss. But it is also sufficient to start the diagnostic investigation if there is 2 consecutive recurrent pregnancy losses or there are losses in the womb after the second 3 months.


What are the reasons?

  • Congenital (Uterus septum, unicornuate uterus, uterine didelphys, bicornuate uterus) or de novo (Uterine fibroids, intrauterine adhesions) anomalies. 
  • Factors related immune system
  • Immune system related factors (Systemic lupus erythemosis, antiphospholipid syndrome)
  • Congenital thrombophilia (Clotting disorders) are directly associated with placental pathologies
 

The following research methods are used in Liv Hospital Ulus Perinatology Clinic

  • Karyotype analysis of mother and father candidates (genetic analysis in blood samples),
  • Ultrasonography, hysterosalpingography (imaging of the uterus and tubes with medication), hysteroscopy, laparoscopy to analyze mother's uterus to research whether there is an anatomical problem in the mother's uterus 4-dimensional, 
  • Conducting thrombophilia panel study in expectant mother blood samples to analyze congenital or de novo thrombophilia (coagulation disorders) and immunological disorders or genetic mutations,
  • Large scale thrombophilia tests including different tests such as lipoprotein A

A precise information can be obtained about chromosome analysis of pregnancy material of women who are pregnant again after recurrent pregnancy loss by implementing interventional procedures such as amniocentesis, chorionic villus sampling, cordocentesis, etc.
 

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